Showing 10963–10976 of 11,469 results for "Ghaeminejad Zeinab"

Journals 2019 EN

Design, Implementation and Evaluation of an Operational Program to Improve the Quality of Basic Clinical Skills in Nursing Students in Zanjan University of Medical Sciences in 2017

Zeinab Bahrami · Saiideh Norouzi · Farhad Ramezanibadr +1 more

Materials and Methods: This study was performed based on the stages of Kern’s framework to enhance basic clinical skills in nursing students in Abhar School of Nursing during 2016-2017 using single-group before-after intervention method. To this end, after recognizing the problem of poor clinical skills in nursing students and a primary needs assessment, the operational program and its method of evaluation were performed after being approved in the educational council of the school. During the research, reaction and knowledge of students before the program were compared to after the program based on the first and second stages of the Kirkpatrick model.

Zanjan University of Medical Sciences
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Journals 2019 EN

Hepatoprotective effects of green tea (Camellia sinensis) on diazinon induced liver damage in female mice

Mahnaz Mohammadi · Firozeh KaramBeigi · Zahra Jamshidi +2 more

Background: Diazinon increases the production of free radicals and hurts the body tissues. The aim of this study was to evaluate the effect of green tea on tissue and liver enzymes in diazinon-treated rats. Materials and methods: In this experimental study, 40 NMRI female mice were divided into 8 groups: control group1 did not receive substance; control group 2 and control group 3 received olive oil and saline, respectively, for 7 days; shamgroup 1 received IP injection of diazinon in dose of 60 mg/kg for 7 days; the sham group 2 and sham group3 received green tea extracts with 200 and 300 mg/kg for 28 days. Experimental group 1 and 2 were treated with 200 and 300 mg/kg green tea extract for 28 days, respectively. Diazinon was prescribed with dose of 60 mg/kg since 14day for 7 consecutive days in the experimental groups. 48 hours after the last injection, liver tissue was studied for histopathologic examination. The level of liver enzymes activity was evaluated. Data were analyzed by ANOVA. Results: The activity of liver enzymes in the control group 1 increased compared to the control group, which decreased after application of green tea extract in experimental groups 1 and 2. The histopathological results showed that hepatocytes were destroyed in the control group 1, while tissue necrosis was not observed in experimental groups 1 and 2. Conclusion: It could be concluded that the consumption of Camellia sinensis normalizes liver enzyme levels and improves liver tissue changes due to diazinon.

Armenian Green Publishing Co.
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Journals 2019 EN

RNA nanotechnology breakthrough for targeted release of RNA-based drugs using cell-based aptamers

Sohameh Mohebbi · Nahid Bakhtiari · Fahimeh Charbgoo +1 more

Nucleic acids play different roles besides storing information and proteins coding. For example, singlestranded nucleic acids can fold into complicated structures with capability of molecular detection, catalyzing bioreactions and therapy. The development of RNA-based therapies has been rapidly progressed in the recent years. RNA aptamers are biomolecules with a size of 10 to 50 nm that can be useful for targeted therapy and systemic release of therapeutics into the desired tissues. Aptamers can be linked to other RNA drugs and form a biohybrid RNA nanostructure. The chemical nature of the aptamers makes them attractive therapeutic agents compared to other small molecules and antibodies. In this review, we discuss different approaches related to drug targeting and release by RNA aptamers, since the importance of the aptamer-based nanomedicine is now well demonstrated and this field become a promising platform in the treatment of diseases.

Armenian Green Publishing Co.
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