Over the last decades, allogeneic hematopoietic stem cell transplantation (allo-HSCT) has considerably improved the outcome of acute myeloid leukemia (AML). Unfortunately, disease relapse remains a frequent occurrence, and a major cause of post-transplant mortality.[1][1] Most salvage treatments do
To determine the reasons for large standard deviation of bronchodilator response (BDR) and establish whether there is a potential heritable component in healthy subjects.
The molecular account of the environmental that epigenetics offers bestow it with paramount importance for biomedical perspective of health and disease and for social sciences perspective on human interactions and well-being. It offers new prospects for interventions to shape the health of both individuals and populations, and invokes its own ethical, legal, and social implications. We here propose treatment of the relation between epigenetics and society through the framework of bio-objectification. After discussing how epigenetic information becomes part of particular bio-identification and bio-objectification processes, we then propose the bio-objectification framework as a fruitful conceptual framework for the analysis of dynamic research and responsive regulatory landscape of this biotechnology.Both authors equally contributed to this text.</p
Tuberculosis is one of the most common diseases in Bangladesh and has variable clinical manifestations. Isolated Hepatic tuberculosis is not a common disease; in fact the presentation of hepatic tuberculosis may be without having history of any active Pulmonary TB or military TB. Patient usually present without having any typical symptoms; so it is difficult for a physician to diagnose the disease quickly. Patient presenting with space occupying lesion in liver is confused with abscess, hepatoma or metastases. Here we are presenting a case report of isolated hepatic tuberculosis. Bangladesh J Medicine Jan 2015; 26 (1) : 43-45
An investigation was carried out on the proximate and mineral contents of widely consumed freshwater small indigenous species (SIS), culture and marine fish species of Bangladesh. Proximate composition (crude protein, fat, ash, moisture, carbohydrate and energy) and selected mineral (Ca, K, Na, Mg, Fe, Zn and Mn) contents were determined eighteen locally available fish species of Bangladesh. Considering proximate composition high protein fishes are Thai Sarpunti 17.5 ± 0.15%, Rui 16.82% ± 0.02; high fat fishes are Thai Pangus 10.03±0.1%, Thai Sarpunti 9.38±0.37%; high Ash contents in Poa 4.78 ± 0.92 %, Ganges Chapila 3.96 ± 0.51%, Thai Sarpunti 3.31 ± 0.14%; high energy found in Thai Sarpunti 157.02 ± 2.61 Kcal/g and Thai Pangus 151.59 ± 2.71 Kcal/g. Considering mineral compositions, Ca rich fishes are Punti 1984.32 ± 1.1 mg, Mola 1267 ± 2.2 mg, Dhela 1717.8 ± 3.1 mg, Chapila 1100.6 ± 1.21 mg, Thai Sarpunti 1373.9 ± 5.32 mg. K rich fishes are Taki 501.47 ± 2.9 mg, Coral 415.24 ± 2.8 mg and Na rich fishes are Thai Sarpunti 780.01 ± 3.8, Ganges Chapila 415.32 ± 2.34 mg, Loitta 497.38 ± 4.21 mg. Trace mineral, Mg is high in Coral 187.98 ± 0.61 mg, Punti 148.16 ± 0.62 mg, Datina 144.05 ± 0.35 mg, Kachki 143.49 ± 0.3 mg fishes, whereas Fe are high in Chapila 15.95 ± 0.03mg, Punti 10.31 ± 0.2, Poa 7.01±0.66 and Zn in Thai Sarpunti 40.20 ± 0.34 mg, Poa 29.32 ± 0.32 mg fishes. Considering Mn, Chapila 6.34 ± 0.04 mg is the highest. This study indicate that small fishes with bones are important source of essential minerals especially Ca. Culture species found to be rich in source of protein, energy and lipids. Marine species exhibit good combination of protein and minerals. This study also encourage to take a culture species like Thai Sarpunti (Barbonymus gonionotus) for its high nutritional meat values and also to consume marine fishes and small fishes with bones for better nourishment. Promotion of the production and consumption of small fishes therefore be encouraged for better nutritional achievement. Bangladesh J. Zool. 42 (2): 251-259, 2014
Background Over the last two decades it has become clear that distinct types of human papillomavirus (HPV), the so-called high-risk types (hrHPV), are the major cause of cervical cancer. The hrHPV-DNA testing has shown excellent performance in several clinical applications from screening to the follow-up of conservatively treated patients. Methods We conducted a systematic review of the recent literature on the performance of HPV DNA testing in follow-up after treatment of high-grade cervical lesions, adenocarcinoma in situ , and microinvasive carcinoma compared to Pap smear cytology. Results Observational studies have demonstrated that the high risk hrHPV-DNA test is significantly more sensitive (95%) compared to follow-up cytology(70%) in detecting post-treatment squamous intraepithelial high-grade lesions. Moreover, in patients treated conservatively for cervical adenocarcinoma in situ , the hrHPV-DNA test is the most significant independent predictor of recurrent disease or progression to invasive cancer, and the combination of viral DNA testing and cytology reaches 90% sensitivity in detecting persistent lesions at the first follow-up visit and 100% at the second follow-up visit. The cause of microinvasive squamous cervical carcinoma is increasingly treated with conservative therapies in order to preserve fertility, and an effective strategy allowing early detection of residual or progressive disease has become more and more important in post-treatment follow-up. Primary results seem to indicate that the median time for viral clearance is relatively longer compared with patients treated for CIN and suggest a prolonged surveillance for these patients. However, the potential clinical value of HPV-DNA testing in this clinical setting needs to be confirmed by further observations. Conclusions The excellent sensitivity, negative predictive value, and optimal reproducibility of the hrHPV DNA testing, currently is considered a powerful tool in the clinicians’ hands to better manage post-treatment follow-up either in cervical squamous lesion or in situ adenocarcinoma.
Since the introduction of biomolecular testing for the identification of high-risk human papillomavirus DNA (hrHPV-DNA) in cervical cancer preventive strategies, many interesting aspects have emerged in this field; firstly, HPV-DNA testing has been demonstrated to have better sensitivity than conventional cytology in several settings: screening, triage of ASC-US and in follow-up after treatment. Despite this, some limitations of these new technologies have also been underlined: the major issue is the low specificity of the tests, which cannot discriminate between regressive and progressive infections. Thus, recent research has moved the attention towards novel markers of progression that could more precisely detect cases at real risk of cancer development. In view of the fact that progression to cancer is dependable of the E6/E7 proteins integration and transforming action, the overexpression of E6/E7 transcripts has been seen as a valuable marker of this risk. This review aims to summarise the literature data on this topic and to provide a clear view of the emerging perspectives.
Acute leukaemias (AL) correspond to 25–35% of all cancer cases in children. The aetiology is still sheltered, although several factors are implicated in causality of AL subtypes. Childhood acute leukaemias are associated with genetic syndromes (5%) and ionising radiation as risk factors. Somatic genomic alterations occur during fetal life and are initiating events to childhood leukaemia. Genetic susceptibility has been explored as a risk factor, since environmental exposure of the child to xenobiotics, direct or indirectly, can contribute to the accumulation of somatic mutations. Hence, a systematic review was conducted in order to understand the association between gene polymorphisms and childhood leukaemia risk. The search was performed in the electronic databases PubMed, Lilacs, and Scielo, selecting articles published between 1995 and 2013. This review included 90 case-control publications, which were classified into four groups: xenobiotic system (n = 50), DNA repair (n = 16), regulatory genes (n = 15), and genome wide association studies (GWAS) (n = 9). We observed that the most frequently investigated genes were: NQO1, GSTM1, GSTT1, GSTP1, CYP1A1, NAT2, CYP2D6, CYP2E1, MDR1 (ABCB1), XRCC1, ARID5B , and IKZF1 . The collected evidence suggests that genetic polymorphisms in CYP2E1, GSTM1, NQO1, NAT2, MDR1 , and XRCC1 are capable of modulating leukaemia risk, mainly when associated with environmental exposures, such as domestic pesticides and insecticides, smoking, trihalomethanes, alcohol consumption, and x-rays. More recently, genome wide association studies identified significant associations between genetic polymorphisms in ARID5B e IKZF1 and acute lymphoblastic leukaemia, but only a few studies have replicated these results until now. In conclusion, genetic susceptibility contributes to the risk of childhood leukaemia through the effects of gene–gene and gene–environment interactions.