Showing 988121–988134 of 988,749 results for "Licciardello Maria"

Journals 2015 EN

New synthetic AICAR derivatives with enhanced AMPK and ACC activation

Olga Scudiero · Ersilia Nigro · Maria Ludovica Monaco +7 more

5-Aminoimidazole-4-carboxamide riboside (AICAR) has an important role in the regulation of the cellular metabolism showing a broad spectrum of therapeutic activities against different metabolic processes. Due to these proven AICAR properties, we have designed, synthesized and tested the biological activity of two ribose-modified AICAR derivatives, named A3 and A4, in comparison to native AICAR and its 5'-phosphorylated counterpart ZMP. Our findings have shown that A3 and A4 derivatives induce the phosphorylation of 5'-AMP activated protein kinase α (AMPKα), which leads to the inhibition of acetyl-CoA carboxylase (ACC), and down-regulate the activity of the extracellular signal-regulated kinases (ERK1/2). Cytotoxicity tests demonstrated that A3 and A4 do not significantly reduce cell viability up to 24 h. Taken together our results indicate that A3 and A4 have a comparable activity to AICAR and ZMP at 0.5 and 1 mM suggesting their potential use in future pharmacological strategies relating to metabolic diseases.

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Journals 2015 EN

Synthesis and biological evaluation of novel peptidomimetics as rhodesain inhibitors

Roberta Ettari · Santo Previti · Sandro Cosconati +4 more

Novel rhodesain inhibitors were developed by combining an enantiomerically pure 3-bromoisoxazoline warhead with a 1,4-benzodiazepine scaffold as specific recognition moiety. All compounds were proven to inhibit rhodesain with Ki values in the low-micromolar range. Their activity towards rhodesain was found to be coupled to an in vitro antitrypanosomal activity, with IC50 values ranging from the mid-micromolar to a low-micromolar value for the most active rhodesain inhibitor (R,S,S)-3. All compounds showed a good selectivity against the target enzyme since all of them were proven to be poor inhibitors of human cathepsin L.

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Journals 2015 EN

Modulation masking release using the Brazilian-Portuguese HINT: Psychometric functions and the effect of speech time compression

John H. Grose · Silvana Maria Sobral Griz · Fernando Augusto Pacífico +2 more

The Brazilian-Portuguese hearing in noise test (HINT) was used to investigate the benefit to speech recognition of listening in a fluctuating background. The goal was to determine whether modulation masking release varied as a function of the speech-to-masker ratio at threshold. Speech-to-masker ratio at threshold was manipulated using the novel approach of adjusting the time-compression of the speech.

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Journals 2015 SP

Acknowledgment of Reviewers

Eva Aguilera

Eva Aguilera Ramón Albero Gamboa Núria Alonso Elı́as Álvarez Laura Audı́ Parera Sharona Azriel Mira Marı́a José Barahona Lluı́s Bassas Lluı́s Berna Roqueta Ignacio Bernabeu Moron Albert Botey Puig Assumpta Caix as Pedragós Amparo Calleja Ismael Capel Gemma Carreras Ana Chico David de Lorenzo Daniel de Luı́s Román Pedro De Pablos-Velasco Carlos del Pozo Picó Ángel Dı́az Pérez Javier Escalada San Martı́n Jose M. Fernández-Real Lemos Josep Franch Nadal Marta Garcı́a Mouriz Ricardo V. Garcı́a-Mayor Garcı́a Gabriel Giménez-Pérez José Manuel Gómez Sáez Maria José Goñi Tomas González Losada Marı́a Luisa Granada Guiomar Pérez de Nanclares Federico Hawkins Carranza Clara Joaquı́n Ortiz Albert Lecube Torelló Esteve Llargués Abel López Bermejo Ana Marı́a Lucas Martı́n Francisco Javier Maravall Marı́a Jesús Martı́nez de Osaba Montserrat Mauri Dı́dac Mauricio Puente Edelmiro Menéndez Torre Francisco Merino Susana Monereo Megı́as Manuel Muñoz Torres Gabriel Obiols Alfonso Gabriel Olveira Fuster Josep Oriola Consuelo Pedrón Ana Silvia Pellitero Rodriguez Jorge Luis Reverter Calatayud Jose Rodrı́guez Espinosa Montserrat Rue Marisol Ruı́z de Adana Isabel Salinas Vert Javier Salvador Rodriguez Jordi Sanahuja Montesinos Joaquı́n Serrano Gotarredona Gemma Sesmilo Federico Casimiro Soriguer Escofet Marı́a Eugenia Torregrosa Federico Tortosa Henzi Luis Vila Núria Vilarrasa Garcı́a Carlos M. Villabona Artero Núria Virgili Ana Wägner Susan M. Webb Youdale

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Journals 2015 EN

Bilateral Renal Dysplasia, Nephroblastomatosis, and Bronchial Stenosis. A New Syndrome?

Maria M. Rodríguez · Mayrin Correa-Medina · Elizabeth Whittington

Bilateral nephroblastomatosis (NB) is an uncommon renal anomaly characterized by multiple confluent nephrogenic rests scattered through both kidneys, with only a limited number of cases reported in the medical literature. Some of these children may have associated either Perlman or Beckwith-Wiedemann syndrome and others do not demonstrate syndromic features. We report a full-term boy with anteverted nose, bilateral bronchial stenosis due to lack of cartilage, bilateral obstructive renal dysplasia and NB with glomeruloid features. The infant had visceromegaly, but neither gigantism nor hemihypertrophy. Immunohistochemistry for PAX2 (Paired box gene-2) and WT-1 (Wilms Tumor 1) were strongly positive in the areas of NB. GLEPP-1 (Glomerular Epithelial Protein) did not stain the areas of NB with a glomeruloid appearance, but was positive in the renal glomeruli as expected. We found neither associated bronchial stenosis nor the histology of NB resembling giant glomeruli in any of the reported cases of NB.

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Journals 2015 EN

Possible Genetic Origin of Limb-Body Wall Complex

David Gajzer · Alicia Hirzel · Gaurav Saigal +2 more

Limb body wall complex (LBWC) is characterized by multiple severe congenital malformations including an abdominal and/or thoracic wall defect covered by amnion, a short or absent umbilical cord with the placenta almost attached to the anterior fetal wall, intestinal malrotation, scoliosis, and lower extremity anomalies. There is no consensus about the etiology of LBWC and many cases with abnormal facial cleft do not meet the requirements for the true complex. We describe a series of four patients with LBWC and other malformations in an attempt to explain their etiology. There are several reports of fetuses with LBWC and absent gallbladder and one of our patients also had polysplenia. Absent gallbladder and polysplenia are associated with laterality genes including HOX, bFGF, transforming growth factor beta/activins/BMP4, WNT 1-8, and SHH. We postulate that this severe malformation may be due to abnormal genes involved in laterality and caudal development.

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Journals 2015 EN

Involvement of NRN1 gene in schizophrenia-spectrum and bipolar disorders and its impact on age at onset and cognitive functioning

Mar FatjóVilas · Claudia Prats · Edith PomarolClotet +16 more

Neuritin 1 gene (NRN1) is involved in neurodevelopment processes and synaptic plasticity and its expression is regulated by brain-derived neurotrophic factor (BDNF). We aimed to investigate the association of NRN1 with schizophrenia-spectrum disorders (SSD) and bipolar disorders (BPD), to explore its role in age at onset and cognitive functioning, and to test the epistasis between NRN1 and BDNF.

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