Journals
2015 PO
Maria José Varandas
O artigo expõe a leitura de Ronald Hepburn sobre a apreciação estética da natureza, considerada como a manifestação da imaginação para a suprema síntese. Pressupondo que se trata de uma experiência multidimensional que mobiliza todas as faculdades humanas, o filósofo escocês sublinha a dimensão metafísica dessa experiência que não só potencia o laço entre o ser humano e o mundo natural, como desvela o significado ético e ontológico dessa relação. Neste sentido, a percepção do belo natural constitui uma via de revelação do humano no seu pleno significado.
Universidade Catolica de Pernambuco
Journals
2015 EN
Peña Sandra · Horia Marin · Rodríguez Felipe
+13 more
B-Chronic Lymphocytic Leukemia (B-CLL) usually follows an adverse, relentless clinical course by slowly developingdrug resistance to fludarabine and other chemotherapeutic agents, as well as by acquiring new different geneticabnormalities. As B-CLL cells spontaneously produce high amounts of Reactive Oxygen Species (ROS) having analtered redox state in relation to that of normal B lymphocytes, we decided to probe different metal Zinc nanoparticles(ZnNPs) and quantify the levels of Singlet Oxigen (SO) to see if variations of its intracellular concentrations couldexecute and accelerate deadly programs in leukemic cells rather than in normal B lymphocytes, when applied withPhotodynamic Therapy (PDT). In this way, we developed and tested a variety of metal ZnNPs of which one made of0.5% Manganese Doped Zinc Oxide (ZnO:Mn) was finally selected for further testing as it had the best fludarabineresistant B-CLL cells in vitro killing activity, specially when combined with PDT. An interesting and rapidly dyingprocess of B-CLL cells, known as autophagy, was always seen under Transmission Electronic Microscopy (TEM) whenincubated with these 0.5% Mn doped ZnO NPs. This phenomenon correlated well with those intracellular increases ofSO when PDT was administered, and measured by a novel method first described by us. As this therapy seems to be veryspecific to fludarabine resistant B-CLL cells, producing almost no damage to normal lymphocytes, it could surelycontribute in the near future as a new innovative targeted strategy to be delivered in the clinical setting for the definitivebenefit of these bad prognostic patients
Dr. Yashwant Research Labs Pvt. Ltd.
Journals
2015 SP
Víctor A. Bolaños · Maria C. Del Vecchio · Rodolfo Á. Golluscio
Ecologia Austral, 25:75-80 (2015) En los pastizales halofitos de la Pampa Deprimida la historia pastoril habria inducido deterioros en la diversidad floristicos y propiedades edaficas. La recuperacion de las especies nativas de alto valor forrajero constituye una valiosa estrategia para la regeneracion forrajera del sistema. Ello requiere un profundo conocimiento de los aspectos ecologicos de estas especies que, en el caso de Chloris berroi, nativa y potencial regeneradora de ambientes degradados, es desconocid. En este trabajo evaluamos dos hipotesis: (1) la dormicion de C. berroi se debe a las estructuras que recubren la cariopside e inhiben su germinacion durante un cierto periodo despues de la cosecha y (2) el establecimiento de plantulas de C. berroi es afectado por el tipo de suelo. Realizamos dos ensayos: uno evaluo el efecto de la remocion de glumas y glumelas sobre la germinacion en semillas de C. berroi con dos tiempos de almacenamiento (2 y 8 meses) y sembradas sobre tres suelos distintos (dos Natracualf tipicos de estepa de halofitas contiguas pero con diferentes historias en el manejo del pastoreo (continuo/rotativo) y un Argiudol Vertico de una pradera humeda de mesofitas con pastoreo rotativo). El segundo evaluo la capacidad de establecimiento de la especie sobre cada suelo. La remocion de la cubierta seminal promovio significativamente la germinacion solo en las semillas de menor tiempo de almacenamiento. El tipo de suelo no afecto la germinacion, en tanto, el establecimiento de plantulas se redujo significativamente sobre el Natracualf bajo pastoreo continuo. Los resultados sugieren que efectivamente las cubiertas seminales inducirian dormicion por algunos meses (< 8). El pastoreo rotativo favoreceria la preservacion de C berroi en las comunidades halofitas y su ausencia en las comunidades vegetales correspondiente a suelos Argiudol vertico no responderia a cuestiones edaficas.
Asociacion Argentina de Ecologia
Journals
2015 SP
M Canepa · Guillermo Montero · Ignacio M. Barberis
Fil: Canepa, Maria E.. Universidad Nacional de Rosario. Facultad de Ciencias Agrarias; Argentina
Asociacion Argentina de Ecologia
Journals
2015 SP
Víctor José Ortega Muñoz
Resena a Maria Dolores Ramos Palomo (coord.): Andaluzas en la historia. Reflexiones sobre politica, trabajo y accion colectiva
Journals
2015 EN
Reinaldo F Cooke · R. F. G. Peres · Rafael Silva Cipriano
+6 more
The objective of this experiment was to evaluate temperament, physiological, and reproductive variables in beef cows assigned to an estrus synchronization + timed AI protocol including eCG administration, 48-h temporary calf weaning (TCW), or TCW + meloxicam administration. A total of 943 lactating, multiparous, nonpregnant Nelore cows, allocated into 8 groups of approximately 120 cows each, were assigned to the experiment. Groups were maintained in individual pastures and assigned to the following estrus synchronization + timed AI protocol: a 2-mg injection of estradiol benzoate and an intravaginal progesterone-releasing device (CIDR) on d 0, a 12.5-mg injection of PGF on d 7, CIDR removal in addition to a 0.6-mg injection of estradiol cypionate on d 9, and timed AI on d 11. Within each group, cows were randomly assigned on d 9 to 1) TCW from d 9 to 11 (TCW-CON; = 317), 2) no TCW and a 300-IU injection of eCG on d 9 (NOTCW; = 311), and 3) TCW-CON in addition to meloxicam administration (intramuscular; 0.5 mg/kg BW) on d 9 (TCW-MEL; = 315). Cow BW and BCS were assessed on d 0. On d 9 and 11, blood samples were collected, and cow temperament was evaluated via chute score and exit velocity. Pregnancy status was verified 30 d after timed AI via transrectal ultrasonography. No treatment differences were detected ( ≥ 0.23) for cow age, days postpartum, BW, and BCS on d 0 of the estrus synchronization + timed AI protocol. No treatment effects were detected ( ≥ 0.41) for any of the temperament variables evaluated. A treatment × day interaction was detected ( = 0.02) for serum cortisol concentrations, which were similar ( = 0.55) between treatments on d 9 but greater ( ≤ 0.05) in TCW-CON and TCW-MEL compared with NOTCW cows on d 11. No treatment effects were detected ( = 0.90) for serum haptoglobin concentrations, which decreased from d 9 to 11 in all treatments (day effect; < 0.01). No treatment differences were detected ( = 0.84) for pregnancy rates to timed AI. In summary, TCW during estrus synchronization did not impact temperament or serum haptoglobin concentrations in beef cows but increased serum cortisol concentrations compared with cows not assigned to TCW, although such an outcome was not sufficient to impact pregnancy rates to timed AI. Moreover, administration of meloxicam did not alleviate the TCW-induced increase in serum cortisol concentrations and failed to benefit pregnancy rates to timed AI in beef cows.
Journals
2015 EN
Maria Carolina Oliveira · Reinaldo F Cooke · Rodrigo S Marques
+3 more
This study evaluated the effects of oral meloxicam administration on metabolic, inflammatory, and acute-phase responses of beef cattle receiving a lipopolysaccharide (LPS) challenge (Exp. 1; d -1 to 6) or vaccinated against respiratory pathogens (Exp. 2; d 7 to 21). Twenty-one Angus steers ( = 11) and heifers ( = 10) were housed in individual pens on d -15 and were offered free-choice water, mineral-vitamin mix, and hay until d 21. In Exp. 1, cattle were ranked on d -1 by sex and BW and assigned to 1) oral meloxicam administration (1 mg/kg BW daily) from day -1 to 6 (MEL8), 2) oral meloxicam administration (1 mg/kg BW) on d 0 and oral lactose monohydrate administration (1 mg/kg BW) on d -1 and from d 1 to 6 (MEL1), or 3) oral lactose monohydrate administration (1 mg/kg BW daily) from d -1 to 6 (CON). On d 0, cattle received an intravenous LPS bolus (0.5 μg/kg BW) concurrently with treatment administration. Rectal temperature (RTEMP) was assessed, and blood samples were collected at -2, 0, 2, 4, 6, 8, 12, 16, 24, 36, 48, 60, 72, 96, 120, and 144 h relative to LPS administration. No treatment effects were detected ( ≥ 0.36) for RTEMP, concentrations of serum tumor necrosis factor α (TNFα), plasma haptoglobin, cortisol, insulin, and leptin, as well as blood mRNA expression of α and cyclooxygenase-2, although all variables increased ( < 0.01) across treatments after LPS administration. In Exp. 2, cattle received the same treatments that they were assigned to in Exp. 1 from d 7 to d 13 and were vaccinated against respiratory pathogens concurrently with treatment administration on d 8. Blood samples were collected, and RTEMP was assessed as in Exp. 1 in addition to 168, 240, and 336 h relative to vaccination. No treatment effects were detected ( ≥ 0.26) for RTEMP, the same plasma and serum variables evaluated in Exp. 1, and serum concentrations of antibodies against or serum titers against bovine respiratory syncytial virus, bovine herpesvirus-1, bovine viral diarrhea virus-1, and parainfluenza-3 virus. All variables increased ( < 0.01) across treatments after vaccination, except for serum TNFα and titers against bovine viral diarrhea virus-1 ( ≥ 0.40). Collectively, this study found no evidence that oral meloxicam administration, at the doses and intervals utilized herein, mitigated the metabolic, inflammatory, and acute-phase reactions elicited by LPS administration or vaccination against respiratory pathogens.
Journals
2015 EN
Maria Christopoulou · Stavros Koulouridis
Pneumothorax is the medical condition caused by the air concentration inside the pleural cavity, the space between the lung and the chest wall. Apart from traditional diagnostic methods, it can be detected by using microwave sensors that capture variations in reflected electromagnetic field (EMF). Sex and obesity, related to the internal composition of the biological tissues, can influence the reflected EMF and therefore the sensor diagnostic ability. This paper investigates the effect on the performance of a proposed on-body dual-patch antenna sensor for pneumothorax diagnosis, due to inter-subject variability in underlying tissue structure. The sensor operates at frequency range of 1-4 GHz. The challenge of the paper is to propose frequency bands for robust and safe sensor operation. S12 parameter alternation versus frequency is assessed for healthy and pathological cases. Implemented thorax numerical models include modified (i) closed rectangular multilayered and (ii) MRI-based anatomical ones. In rectangular models, thickness and configuration of muscle, fat and bone tissues are varied, according to literature. Additionally, sex-related anatomical differences are taken into account in MRI-based models. All scenarios are solved using Finite Difference Time Domain method. Results revealed that the proposed frequency bands lie within 1-2.7 and 2.9-3.5 GHz, for muscle, 1.4-3.5 GHz for fat and 1-2.2 and 2.8-3.5 GHz, for bone variations. Numerical evaluations for accurate anatomical models verify the findings.
The Electromagnetics Academy
Journals
2015 EN
A. M. Pantchenko
N the basis of the archival materials and pre-revolutionary publications there is for the first time comprehensively studied the activities of the son of Emperor Paul I and Maria Feodorovna, Grand Duke Mikhail Pavlovich, being in the capacity of: General-Feldzeugmeister (1819-1849), Inspector General for Engineering (1825-1849), Director-General of Military Educational Institutions (1831-1849), where were laid the foundations of the centralized organization of the officer libraries in the Artillery, Corps of Engineers and in the Military Schools. Under Mikhail Pavlovich, as the Commander of the Guards Corps (1826-1849), the organized officer libraries in the Guards Corps have got its further development. There are presented and analyzed normative legal documents, having made the significant contribution to the history of military librarianship of the Russian Army. Some of them became the basis for the further development of “Statutes”, “Regulations” and “Instructions” of military libraries. There is given comparative characteristics and there are shown some organizational features of the artillery, engineers, combat engineer and regimental guard officer libraries, as well as book collections of the secondary military schools.
Journals
2015 EN
Lidia V. Kroshkina
Analyses biographies of saints and ecclesiastical leaders of both hagiographic and quasihagiographic types written in the 1920s and the 1930s. The author argues that through represented characters she builds her own image of the Church as a holy, communal organism the main characteristics of which are freedom, responsibility, eschatological orientation and creativity.