We analyzed 60 patients aged from 30 up to 75 years with any of low-lumbar herniated intervertebral disks. Pain intensity was compared with the concomitant presence of chronic circulatory failure in the vertebral-basilar basin as a result of clinically significant abnormalities of blood vessels in the form of hypoplasia of vertebral artery and its tortuosity. We investigated dynamics of patient's pain under the influence of low-dose treatment by Cortexin (neurocytoprotector). In patients with chronic brainstem ischemia the herniated discs cause more intense and prolonged pain (radicular and local). More effective in these patients is a treatment with inclusion of Cortexin 20 mg intramuscularly within 10 days.
. The best diagnostic approach for early detection of vascular remodeling in prenosological stage of development the main cardiovascular (CV) diseases has not yet been determined, which inhibits effective vascular screening in the youth population. Objective of the present study was to assess the possible impact of risk factors (RF) on central aortic pressure (CAP) and its augmentation index in young age. Materials and Methods. A total of 80 students (38 girls, 42 boys) were examined in University Center of Student's Health for the presence of major cardiovascular RF and evaluation of CAP in the office format using diagnostic complex BPLab (company «Peter Telegin», Nizhny Novgorod, Russia) on technology Vasotens. In addition to BP in the brachial arterial (BA), the systolic aortic BP (SYSao), diastolic aortic BP (DIAao), index of augmentation in aorta (AIxao), pulse pressure amplification (PPA) and other parameters were analyzed. Surveyed persons were divided into two groups, taking into account the lack of RF ( 26 persons ) and their presence (54 persons). Results. Statistically significant increase in systolic, pulse, average pressure in the aorta and index of augmentation of pulse pressure was revealed in persons with cardiovascular RFs in comparison with those without the specified RFs. Among peripheral hemodynamic parameters, significant difference between the groups was is noted in the value of average pressure. The profile of various options of increase CAP in students as systemic, hidden and false prehypertension / hypertension substantially depends on presence of RF. Conclusion. Obtained data have confirmed the idea about valuability of using the assessment of CAP in Centers of youth's health and Student's policlinics when carrying checkups for the purpose of early detection of CV risk among young people and timely conduct personalized measures for prevention.