Journals
2026 EN
Sahu Sibani · Moharana Maheswata · Das Anuradha
+2 more
Thestructure and function of a protein are closely connected. Changes in a protein structure can impact on its function. Nephrotic syndrome type 4 (NPHS4) is an uncommon genetic condition caused by mutations in the WT1 gene, which codes for the wilms tumor-1 protein. Several studies have discovered that patients with nephrotic syndromes are resistant to steroid therapy and are likely to develop end-stage renal failure. The use of phytochemicals-based therapeutics is in demand due to their high potential and low toxicity. Based on this context, we employed the Autodock raccoon to screen 67 distinct potent phytochemicals from the Boerhavia diffusa (B.diffusa) plant against the wild type and mutant model at position C388R (cysteine is replaced with arginine at position 388) of the C-terminal DNA binding domain of the wilms tumor-1 protein. Out of 67 active compounds, only 10 compounds (lunamarine, kaempferol, boeravinone B, boeravinone E, boeravinone A, boeravinone F, boeravinone J, boeravinone P, boerhaavic acid and 4’,7-dihydroxy-3’-methylflavone) were screened based on drug-likeness properties and binding energy for explicit water ligand docking against wild and mutant model of C-terminal DNA binding domain of wilms tumor-1 protein. Consequently, the hydrated form of boeravinone F and boeravinone A demonstrated the highest binding energy against the protein mutant model described above, the binding energies were −9.56 and −8.96 Kcal/mol, respectively. Followed by explicit water ligand docking the microscopic properties of wild type, mutant, mutant-boeravinone F complex, and mutant-boeravinone A complex systems were evaluated using molecular dynamics simulation steps with 100 ns of trajectory. The findings indicate that, due to mutation the mutant model system had decreasing stability and decreasing compactness nature. However, boeravinone A effectively monitored the mutant system’s stability and improved compactness nature after binding with the mutant model. Boeravinone A with the mutant model complex system was determined to have the lowest energy point as compared to other studied systems. The study revealed minimal structural alterations and reduced conformational mobility.
Journals
2026 EN
Mahuri Monalisa · Paul Manish · Sahu Sumanta Kumar
+1 more
Laccase is an enzyme that belongs to the oxidoreductase family. Because of its delignifying characteristics, it has generated a lot attention as a pretreatment catalyst in the field of biofuel generation. In the present study, sequence and structural aspects of five bacterial laccase enzymes from L. xylanilyticum , P. australiense , O. urethralis , H. muridarum and J. saudimassiliensis have been retrieved from UniProtKB for sequence alignment, phylogenetic analysis using MEGA 7.0 and 3D structure prediction by homology modeling in Phyre2. The modeled laccase enzymes were docked with different ligands viz., ABTS, DMP and guaiacol using AutoDockVina for the relative binding energies between protein and ligand. The Dynamism between enzyme-substrates complex was determined by molecular dynamics simulation using GROMACS software. A comprehensive modeling study of bacterial laccase showed a structural fold, although there are significant divergences in the overall protein sequence, particularly in substrate-binding regions. Analyzing the relative binding energies between protein and ligand in the case of five modeled bacterial laccase enzyme complexes, it was evident that J. saudimassiliensis exhibited the highest binding affinities toward ABTS (−6.80 kcal/mol), DMP (−5.40 kcal/mol), and guaiacol (−5.10 kcal/mol). Molecular interaction investigations underscored the strong affinity of the bacterial laccase from J. saudimassiliensis for its substrates. The Molecular Dynamic simulations indicated that the DMP substrate-bound complex remained notably stable, with an average RMSD value consistently below 0.5 nm throughout a 100 ns timeframe. This in silico investigation might assist in advancing the understanding of bacterial laccase -mediated enzymatic catalysis and its pivotal role in lignin biodegradation.
Journals
2026 EN
Panda Dhruba C. · Raut Biku · Santi Bikash K.
+3 more
This paper presents a hexagonal microstrip patch antenna to generate circular polarization (CP) for sub-6 GHz wireless applications. To enhance the CP bandwidth, two triangular parasitic patches and an edge extension are used in the primary patch. The coupling theory for characteristic modes explains the bandwidth enhancement. The antenna shows an impedance bandwidth of 11.35%; (5.40–6.05 GHz) and axial ratio bandwidth of 4.38%; (5.58–5.83 GHz). It exhibits a peak gain of 5.5 dBic at 5.7 GHz. Owing to its simple structure, improved CP bandwidth, and single-feed structure, the proposed antenna is well suited for WLAN, WBAN, and vehicle-to-vehicle (V2V) communication systems in the sub-6 GHz band.
Journals
2026 EN
Sahu Anjan Kumar · Mahalik Mantu Kumar
Although considerable research has examined the causal rapport between crude oil prices and macroeconomic performance, the interplay between energy import dependence and macroeconomic fluctuations remains unexplored. By employing the pooled mean group autoregressive lag (PMG-ARDL) model, this study is motivated to examine the interplay between energy import dependency and macroeconomic instability in 12 net energy-importing emerging nations from 1996-2019. This study also includes governance quality, bank credit and government spending as important control variables in macroeconomic instability function. The study’s findings demonstrate that reliance on overseas energy hampers macroeconomic resilience. This study further found the positive impact of governance quality and government spending on macroeconomic stability while bank credit adversely influences it. These results were also verified by using the feasible generalized least square (FGLS) method. In terms of policies, this study suggests that increasing energy import dependency should be gradually minimized to enhance emerging economies’ macroeconomic resilience. However, raising energy import tariffs and building energy self-sufficiency could be the key to reducing energy import dependency. This study further suggests that policymakers should consider governance quality and government spending as important determinants of macroeconomic stability. Besides, monetary policy needs to understand bank credit’s adverse impact on macroeconomic stability.
Journals
2026 EN
Tagore G. S. · Sahu Devid Kumar · Mondal Bhabani Prasad
+9 more
In Madhya Pradesh, agricultural soils face constraints, such as nutrient depletion, low fertility in Alfisol, drought and drainage issues in Vertisol, salinity, waterlogging and erosion-driven degradation. Sustainable soil management requires timely soil testing and spatial variability assessment, yet conventional methods are slow, costly and poorly accessible. This study examines visible–near infrared spectroscopy (Vis–NIR) with machine learning to estimate soil pH, electrical conductivity (EC) and soil organic carbon (SOC) from 2216 georeferenced surface samples. Laboratory results showed pH 4.55–8.39, EC 0.03–0.97 dS m⁻¹, and SOC 1.05–11.25 g kg⁻¹, with duplicates confirming high precision. Algorithms tested included partial least squares regression (PLSR), SVMR, ANN, RF, CatBoost, ELM, XGBoost and LightGBM. PLSR delivered the most accurate predictions for pH and SOC, while EC showed moderate predictability. Future research should combine mid-infrared spectroscopy, soil covariates, calibration and global spectral libraries to improve model transferability and support scalable soil health monitoring.
Journals
2026 EN
Namathoti Sivanagaraju · Kumar Sahu Santosh · Sahu Duryodhan
+2 more
Shape memory polymers (SMPs) have garnered great interest due to their remarkable property of recovering their original shape under external stimulus. When combined with 4D printing, such materials hold revolutionary potential in adaptive structures and smart systems with promising implications in numerous applications. This work systematically explores the recovery stress of 4D printed SMPs in a simple and efficient approach. The recovery process was carried out in a water bath under the constraint of a nylon string. Apart from this, the shape recovery motion profiles of SMPs with and without the restraining string were explored to examine the velocity and acceleration of shape recovery during the process. The findings are valuable information on the resulting recovery stress, which was found to be 0.1711 MPa. The findings are important input data for the design of 4D printed SMP actuators and functional devices in general, thus making their development for practical applications easier.
Journals
2026 EN
Meher Rakesh · Sahu Roja · Swain Trupti Rekha
+2 more
This study investigates medicinal plants used for managing dementia by indigenous and non-tribal communities in the Gandhamardan Hill region of Odisha, India. Documenting 48 plant species from 28 families through interviews with 122 traditional healers, the study employed various quantitative indices to assess each species’ ethnopharmacological and scientific significance. Notable families include Acanthaceae, Apocynaceae, and Solanaceae, rich in neuroactive compounds. High values for Fidelity Level and Informant Consensus Factors indicate therapeutic relevance for species like Withania somnifera and Bacopa monnieri. The findings highlight safety concerns, emphasizing the need for dosage standardization and toxicological validation.
Journals
2026 EN
Sahu Jayakrushna · Sahoo Lutu · Parida Rajanikanta
+4 more
In this paper, a double perovskite MgCaFeNbO 6 ceramic was synthesized and systematically investigated to evaluate its potential for negative temperature coefficient (NTC) thermistor applications. The FullProf Rietveld structural analysis performed using recorded X-ray diffraction (XRD) data to confirm the formation of a monoclinic crystal symmetry with. average crystallite size of 108.3 ± 1.7 nm, and the corresponding microstrain was (6.20 ± 0.25) × 10 −5 along with dislocation density 8.52 × 10 13 m −2 . Study of dielectric constant and loss with both frequency and temperature reveals that sample attains maximum dielectric constant of 1125 and loss of 0.4, indicating good quality material for energy storage devices. Study of impedance with frequency reveals a typical negative temperature coefficient of temperature (NTCR) character, decreasing resistance part with increasing temperature. The calculated activation energy values suggested strong thermally activated conduction, dominated by small polaron hopping of localized charge carriers between Fe 2+ /Fe³ + and Nb 4+ /Nb 5+ ions. The study of the electrical modulus versus frequency confirms the presence of a non-Debye type of relaxation. The analysis of both Nyquist and Cole-Cole plots reveals that the studied sample has semiconducting properties and restricted application related to semiconductors. The study of resistance versus temperature provides thermistor constant, sensitivity factor, and activation energy values that fall within the range suitable for practical NTC thermistor applications.
Journals
2026 EN
Dutta Anannya · Khatua Rajashree · Patri S. K.
+3 more
Ba 2FeNbO 6(BFNO) was synthesized by solid state reaction route. The Rietveld refinement of the XRD pattern confirmed a single-phase cubic structure ( χ 2 = 1.72), and the average crystallite size was calculated precisely using different methods. The average grain size of 0.72 µm was found from SEM.Ba 2FeNbO 6shows very low loss (⁓1.2) up to 250° C .The optical band gap (1.4 eV) calculated from UV–Vis spectroscopy assumes a direct allowed transition. The magnetic measurements at room temperature show a predominantly paramagnetic behaviour. The combined structural, dielectric, optical, and magnetic correlations presented in this work make BFNO a multifunctional double perovskite oxide.
Journals
2026 EN
Upasana · Bhattacharya Sankha · Beldar Vishal
+4 more
Colorectal cancer is major cause of mortality, necessitating improved treatments. Lapatinib-loaded chitosan nanoparticles conjugated with lactoferrin and melatonin (LAP-CS-LF-MLT-NPs) developed using ionic gelation and carbodiimide coupling to improve bioavailability and minimise toxicity. Nanoparticles had a size of 184.36 ± 1.25 nm, a zeta potential of +31.88 ± 1.21 mV, and an entrapment efficiency of 68.23 ± 1.69%. FTIR, XRD, DSC, Raman, and NMR validated drug encapsulation, whereas FE-SEM, TEM, and AFM displayed uniform, smooth, spherical structures. In vitro , LAP-CS-LF-MLT-NPs displayed an IC 50 of 0.17 µg/mL in HCT116 cells compared to 127 µg/mL for free lapatinib, indicating a 700-fold enhancement in potency. Further investigations revealed a 48.29% arrest in G1-phase, a 233.44% disruption of mitochondrial membrane potential, and a 4.15% occurrence of late apoptosis, while ROS levels decreased to 54.13%, indicating melatonin’s facilitation of ROS-independent apoptosis. Molecular docking demonstrated strong binding to EGFR (-12.014), SRC (-10.778), and MAPK14 (-10.298). Pharmacokinetic studies in Wistar rats showed a longer half-life (9.69 vs. 5.28 h), higher AUC 0 -∞ (452.880 vs. 159.715 µg/mL·h), and improved MRT (15.260 vs. 7.696 h). Focused colon retention (8.20 ± 1.38 µg/g), minimal toxicity, and confirmed safety and stability underscore its potential as an accurate, efficient treatment for colon cancer.