ABS TRACT Aim of this study to describe the clinical and radiological features of a case of progressive multifocal leukoencephalopathy-immune reconstitution inflammatory syndrome (PMLIRIS) in a patient with multiple sclerosis treated with natalizumab. A 52 years old man with relapsing-remitting multiple sclerosis was switched disease-modifying therapy from glatiramer acetate to natalizumab because of two serious relapses. PML was developed after his 23rd infusion. Five cures of plasma exchange was given. On the follow up, the clinical picture of the patient was deteriorated. He was treated with 10 doses of intravenous methyprednisolone 1 g/day, followed by oral methyprednisolone treatment. He was partially improved and discharged from the hospital 4 months later with a sequel of left hemiplegia and right 4/5 hemiparesis. After 6 months, the patient died because of some systemic problems such as breath insufficiency secondary to aspiration pneumonia and gastric bleeding although there was not any suspicion of a new neurological attack. Natalizumab treated multiple sclerosis patients with any new magnetic resonance imaging (MRI) lesion, mainly subcortical white matter should suggest PML. Those patients should undergo carefull assessment, including serial clinical and MRI monitoring and cerebrospinal fluid analysis.
lism is well known.1 Besides, it is clear that Vit D has additional physiological functions. There are studies about vitamin D deficiency being a risk factor for hypertension (HTA), type 1 diabetes mellitus (T1DM), type 2 diabetes mellitus (T2DM), cardiovascular disease (CVD), and various cancers.2-18 A protective effect of high Vit D against CVD and an inverse correlation between Vitamin D and cardiovascular risks were also suggested.19,20
Bulent Ecevit University, Department of Anesthesia and Reanimation, Zonguldak Turkey Katip Çelebi University, Department of Anesthesiology and Reanimation, Izmir Turkey Bulent Ecevit University, Department of Anesthesia and Reanimation, Zonguldak Turkey Bulent Ecevit University, Department of Cardiology, Zonguldak Turkey Dokuz Eylul University, Department of Anesthesia and Reanimation, Izmir Turkey
DOI: 10.14744/SEMB.2017.58076 Med Bull Sisli Etfal Hosp 2018;52(2):124–128 THE MEDICAL BULLETIN OF SISLI ETFAL HOSPITAL
Avulsion of the flexor digitorum profundus (FDP) and superficialis (FDS) tendons in the same finger as a result of closed trauma is very rarely seen. Here in, the radiological and functional results of 59-year-old male patient treated for avulsion fracture of the FDS tendon combine with avulsion of the FDP tendon in the 4th finger as a result of closed trauma are presented. [Hand Microsurg 2017; 6(3.000): 150-153
We sought to investigate the prevalence of skin tumors in Mugla, which has a Mediterranean climate and a high population of elderly people. This was a cross-sectional study conducted on patients, 65 years old and older, who consulted at our dermatology outpatient clinics between January 2014 and January 2015. Diagnoses of the patients were obtained and retrospectively evaluated from the electronic medical records of the hospital. Of 2297 geriatric patients, 50.8% were females and 49.2% were males. Of these patients, 12% had actinic keratosis, 5.4% had seborrheic keratosis, 2.1% had basal cell carcinoma, 0.8% had squamous cell carcinoma, and 0.1% had malignant melanoma. In patients