Several studies have demonstrated that the electromagnetic fields produce analgesic activity. The aim of this study was to investigate the effects of extremely low frequency (ELF) electromagnetic fields (EMF) on morphine analgesia and tolerance in rats. In the study, 78 adult male Wistar albino rats (approximately 240 ± 12 g) were used. The application of 50 Hz magnetic field, each day the same times for 30 minutes for 15 days, and a total of four times every 15 minute intervals. To constitute morphine tolerance, high dose of morphine (50 mg/kg) were administered for 3 days in rats and tolerance was evaluated on day 4. Prior to analgesia tests, the effective dose (5 mg/kg) of morphine was injected into rats. In the statistical analyzes of the data, analysis of variance (two-way ANOVA) was used and the multiple comparison determined by Tukey tests. The maximum analgesic effect of the 5 mT magnetic field was determined on 7 days. Administration of morphine (5 mg/kg) in rats exposed to a magnetic field, the analgesic effect was significantly higher compared to the morphine group (p < 0.05). Morphine tolerant animals exposed to a magnetic field, the analgesic effect was found significantly higher than morphine tolerant group rats (p < 0.05). Analgesia test data demonstrated that application of ELF-EMFs to rats increases the morphine analgesia and reduces morphine tolerance.
Bioactive glass (BAG) and clodronate are both used for bone regeneration. In this pilot clinical study, we compared the effect of BAG and a novel BAG+clodronate combination as a topical maintenance phase treatment for chronic periodontitis. Two dental residual pockets were treated in each subject (n=10): one with BAG alone and the other with combination product, by applying the products subgingivally for 10 min once a week for four weeks. We describe the effects of these investigational products to the clinical parameters of periodontitis and two bone metabolism markers (osteoprotegerin and osteocalcin). Additionally, subjective satisfaction for the treatment was evaluated. The results must be considered as directional, understanding that further investigation is needed to confirm the findings. Based on clinical parameters measured both treatments could benefit as maintenance therapy for chronic periodontitis. The positive effect of the combination product on tooth sensitivity may bring additional benefits in comparison to the use of BAG alone. Both treatments were well tolerated and safe.
Genetic and transcriptomic factors play important roles as mediators of new-onset and recurrent atrial fibrillation (AF). MicroRNAs (miRNAs) regulate expression of gene networks involved in key aspects of atrial remodeling. Associations between circulating miRNAs and AF recurrence are unknown. We tested the hypothesis that cardiac miRNAs associated with electrical and structural remodeling predict recurrent AF rhythm in post-ablation patients. Methods: We quantified plasma expression of 86 cardiac miRNAs using RT-qPCR in 83 consenting participants undergoing ablation for AF. MiRNA expression was re-measured 1-month post-ablation in a subset of 43 of 83 study participants. Then all 83 patients were followed over a 12-month period for AF recurrence and plasma miRNA expression was compared between baseline and 1-month post-ablation and between those with and without an AF recurrence. Results: The mean age of study participants was 59 years, 34% were female, and 63% had paroxysmal AF. Plasma levels of miRNAs 125a-5p and 10b were 3-fold lower after ablation compared to pre-ablation (p<0.01). Pre-ablation plasma expression of miRNAs 125a and 10b, as well as miRNAs 60, 30a-3p and 199b, were higher among patients with an AF recurrence compared to those without recurrence after ablation (p<0.05) even after adjustment for clinical risk factors. Conclusion: The plasma miRnome is dynamic after AF ablation and associated with AF recurrence. Higher pre-ablation levels of circulating gene regulators implicated in atrial remodeling and AF, including miRNAs 125a-5p and 10b, were associated with AF recurrence and that these same miRNAs decreased post-ablation. Our investigation highlights dynamic gene regulatory networks in patients undergoing ablation and identifies potentially new AF treatment targets.
This paper discuss the effect of processing details such as particle size, sintering temperature, preform preparation, aluminum alloy characteristics and melt temperature on the final mechanical properties of ceramic phase reinforced metal matrix composites. Since alloy composition was determined as 7075 and 7085 optimum solutionizing and ageing temperatures were studied to determine maximum hardness values. For only 7085 alloy best solutionizing temperature is 465°C and for 7075 alloy the maximum hardness achived as 178 BHN after heat treatment at 475°C. Alloys were heat treated for recystallization after hot rolling grain size were measured as 100-120 μm for 7085 alloy matrix. Various sintering temperatures were used for preform preparation such as 1300-1450°C. In 85% Al2O3 reinforced 7085 Alloy based MMCs preforms sintered at 1450°C high hardness values were achieved as 545 BHN. Intermetallic phase was determined in 7075 and 7085 alloys selected as alloy matrix. Al2Cu intermetallic pecipitate (θ phase) was determined as dominant second phase after T6 heat treatment but highly expected phase in 7000 series alloys MgZn2 (η phase) was not determined by XRD and SEM analysis techniques due to ultrafine precipitate size and homogeneous distribution.
The detrimental effects of hyperinsulinemia on human ovaries during follicular development process have been shown in various studies, particularly in women with polycystic ovary syndrome. To our knowledge there is no study regarding the effect of insulin resistance (IR) on the intrauterine insemination (IUI) success in women with unexplained infertility (UEI).
The aim of this study is to define hand choice, reaction time and measurement of some parameters of male and female national athletes competing in short track and curling branches. With collected findings it is aimed to define the dif-ferences between the genders and make a contribution since very limited scien-tific studies are available about these branches in Turkey. Total of 24 of 10 female national athletes with average age of “16.70” and 14 male national athletes with average age of “16.64”. Competing in short track and curling branches were participated to this study. Within the study, Oldfield Edinburg handedness inventory was used for defining athletes’ hand choice and simple reaction test of Davis and Frank is used for measuring reaction time. For the consideration of gained data descriptive statistics is used and independent samples t test is used on 0.05 importance level. According to findings collected from the participants, there is a significant difference in genders in terms of height, leg power, right hand and left hand grip power on 0.05 importance level on behalf of male athletes. There is not a significant difference between male athletes’ branches and average values of measured parameters according to 0.05 importance level. According to variances between branches, values of leg power of male athletes in curling branch are higher than male athletes in other branches. It is found out that average of height, leg power, right hand and left hand grip power of male athletes are higher than female athletes. However, there is not a significant difference between two groups in terms of average values of reaction time and hand choice variances.
Objective: This research was carried out in order to determine the hand and eye dominance (left-hand dominant or right-hand dominant) of the women participating in Turkish senior women’s archery championship and to find out whether there were any differences among the scores gained by the archers as general total and at the end of their 1st and 2nd 50-m target-based shootings when using compound bow. Method: 44 elite-level women archers under the Turkish Federation of Archery participated in the research. We determined the hand dominance and eye dominance of all participants. To determine hand and eye dominance, participants completed the Edinburgh Handedness Inventory-Short Form. According to that, 5 of the archers were left-hand dominant whereas 39 of them were right-hand dominant. A mini survey form was used in order to determine certain bio-motor (age, height, weight and sports age) characteristics of the archers. Results: Laterality might be one of the most significant factors for the archers to become successful. Thus, considering that left-hand dominant archers might gain competitive edge in the archer selection process, these archers can be considered to be advantageous for being selected. Sportive success can be enhanced if trainers attach a particular importance to and support these archers and if they consider this situation particularly during target-based shooting trainings. Furthermore, taking into consideration that left-hand dominant persons are more successful that right-hand dominant persons in certain sports branches, it can be said that, such persons must not be forced to use their right hand.
Brugada syndrome is a disease characterized by a specific electrocardiographic pattern and an increased risk of sudden cardiac death. We present this case with the updated literature to emphasise the need to consider the diagnosis of Brugada syndrome in patients admitted to the emergency ward with sudden cardiac arrest.
Turner syndrome (TS) is a genetic disorder which is characterized by the complete or partial absence of the X chromosome. The incidence is 1/2500 female live births. The main clinical findings are short stature, primary amenorrhea and infertility, and phenotypical features include webbed neck, a low posterior hairline, cubitus valgus and shortening of the fourth metacarpal. While 1% of all still births have 45,X monosomy, this rate has been reported to be approximately 10% in spontaneous abortions. The karyotype is determined as 45,X in about half of the patients. Therefore, most of the TS fetuses are considered to end in spontaneous abortion and only mosaic cases survive to term. Isochromosome Xq is the most common structural rearrangement of the X chromosome. Furthermore, ring X chromosome, deletions and Y chromosome abnormalities can be detected in patients with TS