The inflammatory receptor CD40 is expressed on human adipocytes: contribution to crosstalk between lymphocytes and adipocytes

Obesity is associated with adipose tissue inflammation. The CD40 molecule, TNF receptor superfamily member 5 (CD40)/CD40 ligand (CD40L) pathway plays a role in the onset and maintenance of the inflammatory reaction, but has not been studied in human adipose tissue. Our aim was to examine CD40 expression by human adipocytes and its participation in adipose tissue inflammation.

Continuous low- to moderate-intensity exercise training is as effective as moderate- to high-intensity exercise training at lowering blood HbA1c in obese type 2 diabetes patients

Exercise represents an effective interventional strategy to improve glycaemic control in type 2 diabetes patients. However, the impact of exercise intensity on the benefits of exercise training remains to be established. In the present study, we compared the clinical benefits of 6 months of continuous low- to moderate-intensity exercise training with those of continuous moderate- to high-intensity exercise training, matched for energy expenditure, in obese type 2 diabetes patients.

Transcription of the human uncoupling protein 3 gene is governed by a complex interplay between the promoter and intronic sequences

Uncoupling protein (UCP) 3 is an inner mitochondrial membrane transporter mainly produced in skeletal muscle in humans. UCP3 plays a role in fatty acid metabolism and energy homeostasis and modulates insulin sensitivity. In humans, UCP3 content is higher in fast-twitch glycolytic muscle than in slow-twitch oxidative muscle and is dysregulated in type 2 diabetes. Here, we studied the molecular mechanisms determining human UCP3 levels in skeletal muscle and their regulation by fasting in transgenic mice.

The gait and balance of patients with diabetes can be improved: a randomised controlled trial

Gait characteristics and balance are altered in diabetic patients. Little is known about possible treatment strategies. This study evaluates the effect of a specific training programme on gait and balance of diabetic patients.

Brominated Flame Retardants in Fish of Lake Geneva (Switzerland)

Polybrominated diphenyl ethers (PBDEs) and hexabromocyclododecane (HBCD) were determined in fish (Salmo trutta forma lacustris) from Lake Geneva. Brominated flame retardants were detected in all nine samples with an average concentration for the sum of BDE-28, BDE-47, BDE-49, BDE-66, BDE-99, BDE-100, BDE-119, BDE-153, BDE-154 and BDE-209 of 207 ng per g lipid weight (ng g lw(-1)). The congener patterns were dominated by BDE-47. The average concentration of HBCD was 168 ng g lw(-1).

Comment on “Health-related quality of life as a prognostic factor of survival in critically ill patients”

Reduction of ventilator-associated pneumonia: enhancing knowledge is important

Reply to Wolkewitz et al.

Histopathology of septic shock induced acute kidney injury: apoptosis and leukocytic infiltration

Septic shock is one of the leading causes of acute kidney injury. The mechanisms of this injury remain mostly unknown notably because of the lack of data on renal histological lesions in humans.

Residential equilibrium in a multifractal metropolitan area

A residential location model derived from urban economics is combined with the geometry of a multifractal Sierpinski carpet to represent and model a metropolitan area. This area is made up of a system of built-up patches hierarchically organised around a city centre, and green areas arranged in an inverse hierarchical order (large open-spaces in the periphery). An analytical solution is obtained using a specific geographic coding system for computing distances. The values of the parameters used in the model are based on the French medium sized metropolitan areas; a realistic benchmark is proposed and comparative-statics simulations are performed. The results show that the French peri-urbanisation process (which took place from 1970 onward) can be explained by an increase in income and a reduction in transport costs. Nevertheless, changes in household preferences, in particular an increased taste for open spaces, can also contribute to urban sprawl by making the gradient of land rents less steep and by making peripheral household locations more desirable.