Journals
2009 EN
Randrianalisoa Jaona · Bréchet Yves · Baillis Dominique
Combustion supports which optimize a porous radiant burner are identified using a material selection approach. The optimization requirements account for the environmental aspect such as lower pollution. It was shown that high porosity metallic materials such as FeCrAlY foam, is always preferable in terms of pollution. From the viewpoint of thermal efficiency, metallic foams are better at high in‐flux while Mullite foam takes over at low in‐flux.
Journals
2009 EN
Randrianalisoa Jaona · Baillis Dominique
A combination of analytical and phonon‐tracking approaches is proposed to predict thermal conductivity of porous nanostructured thick materials. The analytical approach derives the thermal conductivity as function of the intrinsic properties of the material and properties characterizing the phonon interaction with pore walls.
Journals
2009 EN
Monnereau Laure · Sémeril David · Matt Dominique
+2 more
The dynamic complex cis ‐ P,P ′‐(η 5 ‐cyclopentadienyl)‐{5,17‐bis(diphenylphosphino)‐25,26,27, 28‐tetrabenzyloxycalix[4]arene}nickel(II) tetrafluoroborate ( 2 ) in which the PNiP plane undergoes a rapid fanning motion was assessed in the cross‐coupling reacting between phenylmagnesium bromide (PhMgBr) and aryl halides (ArX). TOFs, of up to 21250 mol(converted ArBr)⋅mol( 2 ) −1 ⋅h −1 , were obtained with electron‐rich as well as congested bromoarenes using catalyst loadings as low as 1×10 −3 mol%, provided that the reactions were carried out at 100 °C in dioxane with a PhMgBr/ArX ratio of 2:1. The high activities observed contrast with those observed for triphenylphosphine‐based catalysts and furthermore, outperforms the fastest diphosphine‐based catalysts reported, a behaviour which is likely to rely on a bite angle effect.
Journals
2009 EN
Monnereau Laure · Sémeril David · Matt Dominique
+1 more
The combination of calixarene‐derived surfactants and neutral rhodium complexes containing a hemispherical “1,3‐calix‐diphosphite” ligand led to efficient catalysts for the hydroformylation of octene and other olefins in water. While the surfactants allowed the formation of micelles that dissolve both the catalyst and the alkene, thereby resulting in high olefin:rhodium ratios, the diphosphite provided a tight envelope about the catalytic centre able to drive the reaction towards the linear aldehydes. Best results in the hydroformylation of 1‐octene were obtained when using [tetra( p ‐sulfonato)]‐(tetra‐ n ‐butoxy)‐calix[4]arene as surfactant. With this additive remarkable linear to branched aldehyde ratios of up to 62 were obtained, the corresponding activities being higher than those observed when operating in an organic solvent [turnover frequencies (TOFs) up to 630 mol(converted 1‐octene)⋅ mol(Rh) −1 ⋅h −1 ].
Journals
2009 EN
Leclercq Sandrine · Maincent Kim · Baverel Françoise
+4 more
Inverted duplications with terminal deletions have been reported for an increasing number of chromosome ends. The best characterized and most frequent rearrangement reported involves the short arm of chromosome 8. It derives from non‐allelic homologous recombination (NAHR) between two inverted LCRs (low copy repeats) of the olfactory receptor (OR) gene cluster during maternal meiosis. We report here on the cytogenetic characterization of the first inversion duplication deletion involving the short arm of chromosome 20 (inv dup del 20p) in an 18‐month‐old boy presenting with clinical signs consistent with 20p trisomy syndrome. This abnormality was suspected on karyotyping, but high‐resolution molecular cytogenetic investigations were required to define the breakpoints of the rearrangement and to obtain insight into the mechanism underlying its formation. The duplicated region was estimated to be 18.16 Mb in size, extending from 20p13 to 20p11.22, and the size of the terminal deletion was estimated at 2.02 Mb in the 20p13 region. No single copy region was detected between the deleted and duplicated segments. As neither LCR nor inversion was identified in the 20p13 region, the inv dup del (20p) chromosome abnormality probably did not arise by NAHR. The most likely mechanism involves a break in the 20p13 region, leading to chromosome instability and reparation by U‐type exchange or end‐to‐end fusion. © 2009 Wiley‐Liss, Inc.
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Journals
2009 EN
Vons Corinne · Beaudoin Sylvie · Helmy Nada
+3 more
No detailed description of nonhuman primate liver anatomy has been reported and little is known about the similarity between such livers and human liver. The cynomolgus monkey ( Macaca fascicularis ) was used to establish a preclinical model of genetically modified hepatocytes auto transplantation. Here, we report information gleaned from careful observation and notes obtained from 59 female cynomolgus monkeys undergoing 44 anatomical hepatic resections, 12 main portal vein division dissections and selective branch ligations, and 46 portographies. Additionally, three anatomical liver dissections after total resection at autopsy were performed and served to confirm peroperative observations and for photography to provide illustrations. Our results indicate that the cynomolgus monkey liver has four lobes: the median (the largest), the right and left lateral, and the caudate lobes. In 60% ( N =20) of individuals the portal bifurcates into right and left portal veins, in the remaining 40% ( N =14) the portal vein trifurcates into right anterior, right posterior, and left portal veins. The anatomy and branching pattern of the hepatic artery and bile ducts closely follow those of the portal branches. Functionally, the cynomolgus monkey liver can be divided into eight independent segments. Thus, we report the first detailed description of the hepatic and portal surgical anatomy of the cynomolgus monkey. The cynomolgus monkey liver is more similar to the human liver than are livers of any small or large nonprimate mammals that have been described. Am. J. Primatol. 71:400–408, 2009. © 2009 Wiley‐Liss, Inc.
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Journals
2009 EN
Nasidze Ivan · Quinque Dominique · Rahmani Manijeh
+4 more
The Northern Talysh from Azerbaijan and the Southern Talysh from Iran self‐identify as one ethnic group and speak a Northwestern Iranian language. However, the Northern and Southern Talysh dialects are so different that they may actually be separate languages. Does this linguistic differentiation reflect internal change due to isolation, or could contact‐induced change have played a role? We analyzed mtDNA HVI sequences, 11 Y‐chromosome bi‐allelic markers, and 9 Y‐STR loci in Northern and Southern Talysh and compared them with their neighboring groups. The mtDNA data show a close relatedness of both groups with each other and with neighboring groups, whereas the Northern Talysh Y‐chromosome variation differs from that of neighboring groups, probably as a result of genetic drift. This genetic drift most likely reflects a founder event in the male gene pool of Northern Talysh: either fewer males than females migrated to Azerbaijan, or there was a higher degree of relatedness among the male migrants. Since we find no evidence of substantial genetic contact between either Northern or Southern Talysh and neighboring groups, we conclude that internal change, rather than contact‐induced change, most likely explains the linguistic differentiation between Northern and Southern Talysh. Am J Phys Anthropol, 2009. © 2008 Wiley‐Liss, Inc.
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Journals
2009 EN
Benajiba Lina · Le Ber Isabelle · Camuzat Agnès
+15 more
TDP‐43 (TAR‐DNA binding protein) aggregates in neuronal inclusions in motoneuron disease (MND), as well as in frontotemporal lobar degeneration (FTLD) and FTLD associated with MND (FTLD‐MND). Mutations in TARDBP gene, coding for TDP‐43, were found in patients with pure MND. We now describe TARDBP mutations in two patients with FTLD‐MND, presenting with a behavioral variant of FTLD and semantic dementia, suggesting that TDP‐43 may also have a direct pathogenic role in FTLD disorders. Ann Neurol 2009;65:470–474
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Journals
2009 DE
Dettner Frank · Hänchen Anne · Schols Dominique
+3 more
Hochkonvergent verlief die stereoselektive Totalsynthese von Feglymycin ( 1 ) und dessen Enantiomer durch Kupplung sich in der Struktur wiederholender Peptidfragmente. Nur schwach basische Reaktionsbedingungen während des gesamten Syntheseverlaufs unterdrückten eine Epimerisierung empfindlicher Arylglycine. 1 zeigt nicht nur eine bemerkenswerte Anti‐HIV‐Aktivität, sondern, entgegen früheren Ergebnissen, auch eine beachtliche antibakterielle Aktivität gegen Staphylococcus aureus.
Journals
2009 DE
Quideau Stéphane · Lyvinec Gildas · Marguerit Mélanie
+5 more
Auf Iod kommt es an : Mit dem Iodaren in doppeltem Überschuss entstehen bei der Titelreaktion in guten Ausbeuten ortho ‐Chinole, während organokatalytische Versionen der Reaktion eine anschließende regio‐ und diastereoselektive Epoxidierung ermöglichen. Mit chiralen Iodbiarenen werden Enantioselektivitäten bis 50 % ee erreicht. m ‐CPBA= meta ‐Chlorperoxybenzoesäure.