Predictive prognostic scoring (PS) systems are not primarily applicable to elderly patients with classical Hodgkin lymphoma (cHL). The objective of this study was to develop a PS system for these patients. The derivation cohort (DC) was utilized for model development, consisting of 97 variables. The resulting algorithm was named as Hodgkin’s Lymphoma Early Death in the Elderly within 12 months (HEDEL12). Internal and external validation cohorts (IVC and EVC) were employed for validation. A total of 286 patients were evaluated retrospectively. In DC 38 of 178 patients died within the first 12 months and overall survival (OS) at 12-month was 78.6%. Independent predictors of HEDEL12 were female sex, low albumin levels (<3.5 g/dL), and ECOG scores 2-4. According to HEDEL12 scores 0–1, OS at 12- months were 89.8% and 91.0% for IVC and EVC, respectively. The HEDEL12 scoring is useful in predicting the survival of advanced-stage cHL patients.
With the developments in the automotive sector and the increase in the number of automobiles, the need to dispose of expired tires has also increased. Operations such as the storage and transportation of waste tires without harming the environment cause great costs. The present study investigated the availability of products that can be obtained through thermochemical processes from waste tires that have reached the end of their lifespan. The tires were pyrolyzed in an inert gas environment at high temperatures to obtain pyrolytic oil, carbon black, and gas. It was aimed at increasing the product quality by adding different brands of sediment crushers and 2-ethyl-hexyl-nitrate from different countries at various ratios to the pyrolytic oil obtained. The RON and MON values of the product were 92.8 and 78.9, respectively. These results show that it is possible to improve the light product fraction to be close to gasoline specifications by blending with conventional gasoline fuel. Moreover, the product has a density of 989.9 kg/m3 and can be blended with marine fuels by the relevant standards with 4.68% carbon residue values, so that pyrolysis fuel can also find use in the shipping industry. Waste gas, one of the outputs of the pyrolysis process, was also evaluated within the scope of this study. It was mixed with pyrolysis fuel and used for fuel enrichment (80% pyrolytic oil + 20% pyrolytic gas). Although it produces less torque and power than conventional diesel fuel, it is concluded that the combustion characteristics of the engine can be improved compared to the use of pyrolytic oil alone as fuel. Because of the study, an alternative fuel was obtained by evaluating both the disposal of waste tires and the liquid and gaseous components released as a result of disposal.