Journals
2025 EN
Wada Naotoshi · Nomura Tetsuya · Kato Yukinori
+1 more
ABSTRACT Epidemiological studies in the general European population have shown high prevalence rates for nickel (Ni) allergy, despite its wide usage. As commercially available coronary stents contain Ni, they are contraindicated in patients with metal allergies. Although PROBIO coating can suppress the elution of metal ions, its real‐world use in patients with metal allergies has not been reported. A 73‐year‐old man presenting with exertional chest pain was referred to our cardiology clinic. Coronary computed tomography revealed severe stenosis of the right coronary artery (RCA), and coronary angiography (CAG) revealed severe stenotic lesions in the proximal and distal RCA. As the patient reported a metal allergy, patch tests were performed on 15 metal components and five stents. Moderate allergic reactions to Ni‐ and CoCr‐EES were confirmed. The patient refused to undergo coronary artery bypass surgery; hence, we performed percutaneous coronary intervention (PCI) with an initial stent‐avoidant approach. Because intravascular ultrasound showed positive remodeling, a plaque with echo attenuation, and a mural thrombus at the culprit lesion, we decided to directly implant a CoCr‐SES with PROBIO coating Orsiro Mission (BIOTRONIK, Berlin, Germany) 3.5 × 26 mm. Follow‐up CAG 56 days after PCI showed good stent patency. Optical coherence tomography imaging showed coverage of 92% (1155/1249) of the struts (29% embedded) and no obvious thrombus formation. Follow‐up CAG 408 days after PCI showed coverage of 98% (958/979) of the struts (70% embedded) and no peri‐stent contrast staining. Therefore, CoCr‐SESs with PROBIO coating may be an effective treatment option in patients with metal allergies; however, this is a case report, and further research and registry data are required.
Journals
2025 EN
About this conference It is our great pleasure to welcome you to the 21st International Probabilistic Workshop (IPW 2025), held from 10–12 September 2025, in the historic city of Rostock, Germany. Since its inception in 2003 in Dresden, the IPW has grown into a globally recognised forum for the exchange of knowledge on probabilistic methods in engineering, drawing together researchers, practitioners, and students from a wide range of disciplines. From its roots in Germany to recent editions across Europe and beyond, the workshop series has continuously advanced the discourse on risk, reliability, and uncertainty in civil and infrastructure engineering. This year's edition takes place at the University of Rostock, an institution with a proud academic tradition dating back to 1419 and a forward‐looking approach in civil engineering education and research. Rostock, with its maritime heritage and dynamic academic community, offers an ideal setting for vibrant discussions and new collaborations. IPW 2025 continues the tradition of fostering rigorous intellectual exchange while embracing emerging challenges and technologies. While the workshop remains open to a broad spectrum of contributions in probabilistic engineering, particular emphasis is placed on current developments such as the integration of machine learning and artificial intelligence, advanced statistical modelling, and precise uncertainty quantification. The growing relevance of climate resilience and extreme event modelling across the life cycle of infrastructure systems is also prominently featured. We are confident that the contributions presented in this volume will inspire further research and dialogue, and that the workshop will serve as a catalyst for innovation and cooperation across disciplinary boundaries. We thank all participants, authors, reviewers, and contributors for making IPW 2025 a memorable event. Your engagement sustains the workshop's spirit and its mission to advance probabilistic approaches in engineering. Review Process All papers published in this issue were peer‐reviewed by the Scientific Board of the conference organizer in a single‐blind process. The review process for this conference was a multi‐stage process. In the first phase, a Scientific Board of experts from the main conference topic areas was organised. The Organising Committee has centrally invited authors to submit abstracts for the corresponding mini‐symposia via the ScholarOneManuscripts Platform. The registration of the abstracts according to the Wiley Publications and Registration Processes also takes place from this platform. The submitted abstracts were reviewed by the International Scientific Committee Members and subsequently approved by the handling Scientific Secretary. Subsequently, the authors were invited to submit their full paper contributions via the Wiley Publications ScholarOneManuscripts Platform. The review process and also the revision process of the full papers were carried out in accordance with the ScholarOneManuscripts as above. All submitted papers were reviewed in a single‐blind peer review procedure from members of the scientific committee.
Journals
2025 EN
Sobral Margarida C. · Mota Sandra I. · Oliveira Paulo J.
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Prostate cancer (PCa) is a significant healthcare challenge, associated with considerable mortality and morbidity among men, particularly in developed countries. PCa mortality and morbidity are primarily related to its most advanced form, metastatic castration‐resistant PCa (mCRPC), for which there is presently no cure. Therefore, novel therapeutic approaches to increase mCRPC survival are critically needed. Due to PCa tumor heterogeneity and a complex tumor microenvironment, the efficacy of single‐target radiopharmaceuticals, such as the Food and Drug Administration‐approved [ 177 Lu]Lu‐PSMA‐617, is currently under reassessment. The design and development of PCa dual‐target radiopharmaceuticals have garnered considerable attention, due to their benefits over single‐target counterparts, namely increased therapeutic specificity and efficacy, as well as the ability to overcome the challenge of inconsistent tumor visualization caused by variable receptor expression across diverse lesions, thereby enabling more comprehensive imaging. Several PCa biomarkers are currently being investigated as potential targets for dual‐target radiopharmaceuticals, including prostate‐specific membrane antigen, gastrin‐releasing peptide receptor, integrin α v β 3 receptor, fibroblast activation protein, sigma‐1 receptor, as well as albumin, the radiosensitive cell nucleus, and mitochondria. This review explores recent advancements in heterobivalent metal‐based radiopharmaceuticals for dual targeting in PCa, highlighting their significance in theranostic and personalized medicine.
Journals
2025 EN
Ip Ching Yin
ABSTRACT This research analyzed how perceived mission adherence (PMA) and perceived corporate social responsibility (CSR) fit influence consumer responses toward social businesses. No study has explored the role of CSR fit within social businesses, and limited CSR‐related research has integrated attribution theory with the theory of planned behavior (TPB). The present study addressed these gaps by combining the aforementioned theories to investigate how perceived CSR fit functions within social enterprises. This research examined the mediating effects of CSR authenticity and CSR skepticism on the relationships of perceived CSR fit and PMA with purchase intention and positive word‐of‐mouth (PWOM). It also evaluated the relevance of TPB‐related constructs in predicting consumer engagement with social business products. Two studies were conducted in Taiwan by using an experimental survey design. Study 1 suggested that PMA positively influenced perceived CSR fit and CSR authenticity and negatively affected CSR skepticism, leading to stronger purchase intention and PWOM. Study 2 considered TPB‐related variables, confirming that attitude influenced purchase intention and PWOM, whereas subjective norms had a significant effect only on PWOM. The findings of this study extend attribution theory by revealing that PMA influences attributions of CSR motives of social businesses. Furthermore, this study refines the TPB by showing that subjective norms primarily drive advocacy rather than purchase intention. The results of this research highlight the crucial roles played by mission alignment, transparency, and social influence in fostering consumers' trust in and engagement with social businesses.
Journals
2025 EN
AlAsfour Fadi
ABSTRACT This study investigates the relationship between corporate social responsibility (CSR) disclosure and financial performance among Islamic banks in the Gulf Cooperation Council (GCC) region from 2000 to 2024. Drawing on a unique CSR disclosure index grounded in AAOIFI standards and content analysis of 285 annual reports from 35 fully‐fledged Islamic banks, the study finds a robust positive association between CSR disclosure and both current and future financial performance. While the composite CSR index shows strong positive effects, only two individual dimensions—“mission and vision” and “products and services”—are significantly correlated with improved financial outcomes. The results remain consistent across alternative profitability measures and withstand endogeneity checks. This research extends the stakeholder and good management theories to the context of Islamic finance and highlights the strategic value of CSR in aligning financial performance with Islamic ethical principles.
Journals
2025 EN
Yan Xiaojun · Duan Wanxin · Wang Xiangdong
Abstract Marine biomedicine is an important field in oceanology and bio‐ecosystem and has evolved significantly alongside advances in biotechnology and growing understanding of marine life. In this perspective, we propose a refined concept of clinical marine biomedicine, with a clear mission to establish an emerging discipline that bridges marine biomedicine and clinical practice. The exploration of marine‐origin sources should be emphasised, with a strong focus on the identification, validation and development of human disease‐specific diagnostics and target‐oriented pharmaceutics. The perspective headlines some of critical components, including marine‐oriented human evolution and development, humanised marine‐based models, biomarker innovation and validation, marine microbiomes and metabolites, and target nutrition and therapy. We envision that clinical marine biomedicine will become a crucial pillar clinical molecular medicine, contributing to the improvement of human health and the prognosis of patient.
Journals
2025 EN
Yan Xiaojun · Duan Wanxin · Wang Xiangdong
Abstract Marine biomedicine is an important field in oceanology and bio‐ecosystem and has evolved significantly alongside advances in biotechnology and growing understanding of marine life. In this perspective, we propose a refined concept of clinical marine biomedicine, with a clear mission to establish an emerging discipline that bridges marine biomedicine and clinical practice. The exploration of marine‐origin sources should be emphasised, with a strong focus on the identification, validation and development of human disease‐specific diagnostics and target‐oriented pharmaceutics. The perspective headlines some of critical components, including marine‐oriented human evolution and development, humanised marine‐based models, biomarker innovation and validation, marine microbiomes and metabolites, and target nutrition and therapy. We envision that clinical marine biomedicine will become a crucial pillar clinical molecular medicine, contributing to the improvement of human health and the prognosis of patient.
Springer Science+Business Media
Journals
2025 EN
Li Lingfei · Zhang Qinglou · Xiong Xuanrui
+2 more
ABSTRACT The industrial internet of things (IIoT) confronts dual challenges in wireless sensing networks (WSN): achieving interoperability among heterogeneous devices while ensuring mission‐critical security and ultrareliable low latency communication (URLLC). Current solutions exhibit two key limitations: inability to capture multiscale temporal dependencies in nonstationary sensor streams and lack of physics aware deep learning architectures for security sensitive predictive maintenance. To address these gaps, this article proposes IIoT‐FSO, an intelligent framework integrating deep learning with free‐space optical (FSO) channel dynamics. Leveraging FSO strengths (GHz level modulation bandwidth, millimeter precision beam confinement, and electromagnetic resilience), the framework establishes new benchmarks for atmospheric channel modeling in adaptive photonic systems. A core innovation lies in a hybrid neural architecture that combines gated recurrent units (GRUs), long short‐term memory (LSTM) networks and attention mechanisms. This architecture integrates spatial pattern recognition capabilities of CNNs, temporal dynamics modeling by GRU and LSTM (for capturing spatiotemporal dependencies), and adaptive weighting of critical turbulence features across scales via the attention mechanism. Experimental results demonstrate significant performance improvements in FSO communication link prediction. Multivariate analysis (attenuation, additional losses, and beam divergence based on sliding window algorithm) shows that the attention‐LSTM model achieves 76.83% accuracy, while the CNN‐GRU‐LSTM architecture reaches 80.13% accuracy, both outperforming conventional methods. This article advances the technical readiness of IIoT for secure and low latency industrial applications, highlighting its potential to reshape smart manufacturing paradigms enabled by WSN. A neural network model is based on attention mechanisms for the industrial internet of things free‐space optical (IIoT‐FSO) framework. The model effectively captures the dynamic variations of the atmospheric channel and enhances the reliability of wireless sensor networks through multiscale spatiotemporal feature extraction.
Journals
2025 EN
Tribble Dana · Holt Aubrey · Gordon Sarah
To best support women in higher education, especially those balancing complex professional and personal roles, deepening our understanding of their lived experiences is critical. From those experiences, we can build meaningful support structures that truly meet their needs. As passionate educators and advocates, we, Drs. Dana Tribble, assistant professor of higher education and student affairs at Arkansas Tech University; Aubrey Holt, visiting lecturer of leadership studies at Arkansas Tech University; and Sarah Gordon, dean of the Jackson College of Graduate Studies at University of Central Oklahoma; held leadership positions in Arkansas higher education and officer positions with the Arkansas Council for Women in Higher Education (ACWHE). ACWHE's mission is to promote institutional change, elevate women's voices, and advocate for meaningful support in higher education.
Journals
2025 EN
Thevis Mario · Kuuranne Tiia · Geyer Hans
ABSTRACT The 17th edition of the annual banned‐substance review on analytical approaches in human sports drug testing is dedicated to literature published between October 2023 and September 2024. As in previous years, focus is put particularly on new or enhanced analytical options in human doping controls as well as investigations into the metabolism and elimination of compounds of interest, which represent central (while not exclusive) cornerstones of the global anti‐doping mission. New information published within the past 12 months on established doping agents as well as new potentially relevant substances are reviewed and discussed in the context of the World Anti‐Doping Agency's 2024 Prohibited List. Thereby, analytical challenges, especially with regard to the continuously growing number of target compounds and potentially relevant drug classes as well as the exigency (and consequences) of utmost analytical retrospectivity, are thematized and contextualized. Investigations especially into anabolic agents, peptide hormones, and strategies for the detection of gene doping were identified as core areas of anti‐doping research in the reviewed period.