The main purpose of the paper is to identify the controllability of an existing production system; yogurt production line in Abu Ghraib Dairy Factory which has several machines of food processing and packing that has been studied. Through the starting of analysis, instability in production has been found in the factory. The analysis is built depending on experimental observation and data collection for different processing time of the machines, and statistical analysis has been conducted to model the production system. Arena Software is applied for simulating and analyzing the current state of the production system, and results are expanded to improve the system production and efficiency. Research method is applied to contribute in knowing and expecting the future running of the system to enhance the controllability of the system production and improve the production system and machine efficiency. Moreover, built an experiment-real model in Arena in order to control the system in term of production and process. First step is to collect the statistical data required for analysis in terms of input and output data for analysis. Second, is to track the production problem in term of process bottleneck in order to improve the utilization of the system. Third is to validate the model in order to overcome the product demand of the system uncontrollability. Through the result analysis of waiting time and production rate, it is clearly shown that system is stable with a need to resetting the capacity as a chance for the improvement, regarding to resources utilization. Re-planning resources capacity positively enhances the production and profitability of the system.
Objective: Cancer is the deadliest disease affecting the life of the people all around the world. Colon cancer is the cancer which is affecting the colon region it is the last part of the gastrointestinal tract which is mainly responsible for the absorption of water and minerals from the food debris. Colon cancer is the second most cancer creating death in the world. It affects both male and female equally. Curcumin is a flavonoid used from decades for the treatment of various ailments including cancer. This present work is to formulate Self-nanoemulsifying drug delivery (SNEDDS) system with the help of curcumin for colon delivery. Materials and Methods: Nanoemulsion was prepared using the curcumin pre-concentrated self-nanoemulsifying drug delivery system, with which tablets were prepared and coated with pectin followed by the evaluation test such as in vitro dissolution and cell line studies. Results: Solubility profile of curcumin was found with a greater impact using Capmul MCM and Labrafac PG which is then added with the surfactants and co-surfactants and were converted into Nano-droplets. F1 formulation was selected after carrying out the characterisation studies and converted into a tablet dosage form and then coated with pectin, in vitro studies depicted a release of 80% in pH 6.8. Conclusions: Formulation of a solid self-Nano emulsifying drug delivery system using curcumin was successfully carried out. From the results obtained, the formulation (F1) was selected for the formation of the tablets and the further experimental part is carried out. The tablet dosage form is then coated with pectin and used for targeting the colon cancer cells for its treatment.
Subsequently, the early reactivation or old human cytomegalovirus (HCMV) infection may be interfere with IgE and interleukin-33 (IL-33) levels disturbances throughout the life intervals and act as synergistic factors to play a significant role in the pathogenesis of various diseases; like asthma or coronary heart diseases (CHD). The main subject of the current study was to determine the role of CMV infection onto IgE levels and IL-33 disturbances in the pathogenesis of asthma and atherosclerosis as a case-control study. A total of 175 participants were with a mean age of 38.17 ± 7.51 years [age range: 26–52] years, which were distributed as patients with atherosclerosis (n=50) and asthmatic patients (n=50) as the cases of our study and 75 healthy subjects as a control group. Both groups of asthmatic and atherosclerosis patients show a significant association with the seropositivity of CMV-IgG which was detected in 33 (18.9%) and 30 (17.1%). While, CMV-PP65 Ag which was detected in 26 (14.9%) and 28 (16.0%) respectively (P < 0.0001). High level of abnormal IL-33 was detected in 36 (20.6%) with 45 (25.7%) of abnormal IgE was determined in patients with asthma followed by 26 (14.9%) and 44 (25.1%) for abnormal levels of IL-33 and IgE respectively in patients with atherosclerosis. Furthermore, there was a positive significant association between the seropositivity of CMV-IgG and CMV-PP65 Ag with abnormal IgE and IL-33 levels in the pathogenesis of asthma and atherosclerosis (P < 0.0001), and impact of our study support the hypothesis that previous cytomegalovirus infection or early reactivation with unregulated IL-33 expression or high IgE level play a significant role in the pathogenesis of coronary heart diseases and asthma.
Controlled release dosage form is a dosage forms that release the drug continuously in predetermined pattern for a fixed period of time, either systemically or locally to specified target organ.1 It occurs when the active constituents and polymer both combined in such manner that the release from the bulk mate rials was predesigned; its role is to alter the pharmacokinetics and or pharmacodynamics of pharmacologically active moie ties by using novel drug delivery system or by modification of molecular structure or its physiological parameters.2 Emboliza tion technique is a technique in which an occlusive drug is delivered through a catheter to block flow within a targeted blood vessel. It is performed for many medical conditions such as discontinue bleeding from a hemorrhagic ulcer or to tumor by blocking its blood supply.3 Ion exchange resin microspheres can be used to induce emboli after loading with the suitable drug and in order to obtain the suitable particle size to block the blood supply microencapsulation technique can be applied.4 The polymer used as a coated material is poly(lacticcoglycolic acid) (PLGA) which is a family of FDAapproved biodegradable polymers that are physically strong and highly biocompatible and have been extensively studied as sustained delivery vehicles for drugs.5 Coating (microencapsulation) of the microspheres loaded drug like drug–resin complex (DRC) provided better control on the release of the drug by utilizing ratecontrolling membrane that can modify the action of the therapeutic emboli for a longer time.6 Sulfasalazine is tasteless, odorless, brownishyellow powder with 542°C melting point. It is indicated in the treatment of mild to moderate ulcerative colitis, it is also indicated in rheuma toid arthritis, juvenile rheumatoid arthritis, Crohn’s disease and psoriatic arthritis.7 Sulfasalazine has a potent inhibitory property
Objective: This work involves preparation and evaluation (in vitro/ in vivo) of microcapsules containing sulfasalazine- ion exchange resin complex (resinate) to induce emboli for treatment of solid cancer. Methods: The drug resin complex (resinate) had been optimized by using drug: resin ratio (1:8), by suspending the resin in sulfasalazine aqueous solution with at 400 rpm for 120 minutes at 50 ºC. For controlling the release of drug, microencapsulation for the resinate was applied where 21 formulas with different resinate: PLGA ratios 2:1, 1:1, 1:2 were prepared by solvent evaporation method to study the effect of different variables including resinate: polymer ratio, stirring speed, effect of temperature and aqueous phase volume on microencapsulation efficiency and percent yield. Results: The in-vitro release study for the prepared resinate, which had 72% entrapment efficiency, showed 80.992 % of drug released within 15 minutes and the release continued until 99.83% within 75 minutes formula was found to be F19 had 76.70% encapsulation efficiency and 89.40% percent yield. The in vitro release study for selected formula showed that 32% of drug released within 1hour and 78% of drug released within 20 days and the release continued up to 96% within 45 days indicating a controlled release manner with spherical microcapsule of 595µm. The preliminary in vivo work using rabbits showed instant occlusion of the central auricular artery of the rabbit ear leading to ischemia within 3 days that continued to the end of study period Conclusion: This work show the suitability of microcapsules size to prevent blood flow and forming embolization with controlling release of the drug that may treat the solid tumor.
The future smart cities vision can be developed through leveraging the potentials of Internet of Things (IoT) and wireless sensor network (WSN) technologies. WSN is a resource constrained network where network nodes are tiny devices that are run on battery power. Diverse types of applications such as environmental and habitual monitoring, detection, and tracking, use WSNs. The invention of new network protocols, the establishment of new models for communications, and testing the available solutions in real world environment are some of the current research issues in WSNs. Main challenges in such networks include energy conservation in an efficient way, dealing with variable channel capacity, and the resource constrained nature of such networks. The design of architecture for such networks has a vital role in solving the issues to some extent, i.e., the cross layer design approach is an architectural technique that offers the interaction of different layers together to enhance the performance, minimize the energy consumption, enhance the network life time, and provide Quality of Service (QoS) in real time communications. These are some of the current areas where cross-layer design approaches are being used. This paper presents different types of cross-layer design techniques in wireless multimedia sensor networks. Using such architectural techniques, different state of the art cross-layer optimization approaches are discussed while giving the reader an insight on prominent challenges and issues along with future directions.