Human Leukocyte Antigen (HLA) class I and II datasets for sudanese

Sudan is located in the heart of Africa and surrounded by eight countries with people of different ethnic origins. Historical records show that the population of the Sudan is a mixture of Arabic, West Asian Arabic and sub-Saharan African elements. The present survey provides data on allele lineages, and haplotype frequencies of Human Leukocyte Antigen (HLA) class I (HLA-A and HLA-B) and class II (HLA-DR and -HLA-DQ) loci in 11 Sudanese populations. The sampled individuals are all local transplant donors who provided informed consent for HLA analyses on their blood samples and were registered at National Cancer Institute, University of Gezira, Wad Medani. The HLA class I and II data reported here can be subjected for future analyses of genetic structure and health in Sudan. These include as reference datasets for identifying the association between HLA and diseases and for designing donor recruitment strategies.

A large epithelioid angiomyolipoma of the kidney in a very young child with idiopathic chylothorax: A diagnostic dilemma

Epithelioid angiomyolipoma (EAML) is a subtype of angiomyolipoma, the most common benign renal tumour and usually asymptomatic until adulthood. This paper reports a patient with EAML identified at 30 months, the youngest age of presentation with this tumour reported in the literature. In this case the tumour was extremely large andwas successfully surgically removed. Furthermore, the patient had no other TS features, presented with acute symptoms, and had bilateral idiopathic chylothorax which was managed by octreotide and diet.

The wonders of BMP9: From mesenchymal stem cell differentiation, angiogenesis, neurogenesis, tumorigenesis, and metabolism to regenerative medicine

Although bone morphogenetic proteins (BMPs) initially showed effective induction of ectopic bone growth in muscle, it has since been determined that these proteins, as members of the TGF-β superfamily, play a diverse and critical array of biological roles. These roles include regulating skeletal and bone formation, angiogenesis, and development and homeostasis of multiple organ systems. Disruptions of the members of the TGF-β/BMP superfamily result in severe skeletal and extra-skeletal irregularities, suggesting high therapeutic potential from understanding this family of BMP proteins. Although it was once one of the least characterized BMPs, BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo , with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs. The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants, revealing the great translational promise of BMP9. Furthermore, emerging evidence indicates that, besides its osteogenic activity, BMP9 exerts a broad range of biological functions, including stem cell differentiation, angiogenesis, neurogenesis, tumorigenesis, and metabolism. This review aims to summarize our current understanding of BMP9 across biology and the body.

Stem cell therapy for chronic skin wounds in the era of personalized medicine: From bench to bedside

With the significant financial burden of chronic cutaneous wounds on the healthcare system, not to the personal burden mention on those individuals afflicted, it has become increasingly essential to improve our clinical treatments. This requires the translation of the most recent benchtop approaches to clinical wound repair as our current treatment modalities have proven insufficient. The most promising potential treatment options rely on stem cell-based therapies. Stem cell proliferation and signaling play crucial roles in every phase of the wound healing process and chronic wounds are often associated with impaired stem cell function. Clinical approaches involving stem cells could thus be utilized in some cases to improve a body's inhibited healing capacity. We aim to present the laboratory research behind the mechanisms and effects of this technology as well as current clinical trials which showcase their therapeutic potential. Given the current problems and complications presented by chronic wounds, we hope to show that developing the clinical applications of stem cell therapies is the rational next step in improving wound care.

P3‐252: SERUM OXYLIPINS INDICATE VASCULAR COGNITIVE IMPAIRMENT IN ALZHEIMER'S DISEASE WITH COMORBID CEREBROVASCULAR DISEASE: A PRELIMINARY REPORT

Management of elbow arthritis by interposition arthroplasty with abdominal dermal graft

Interposition arthroplasty (IA) is one of the oldest reconstructive options for elbow arthritis and is an alternative to total elbow arthroplasty in young active patients with moderate to severe elbow arthritis. In literature there is very little, if any, mention about relationship of post-operative functional recovery and time. In this study we assess the clinical and functional outcome of interposition arthroplasty using abdominal dermal graft.

Effect of nano-TiO2 on the properties of cementitious composites under different exposure environments

This article presents the effect of 1%, 3% and 5% content of nano-TiO2 (NT) on the fresh, hardened, microstructural and corrosion resistance properties of cementitious composites under different exposure environments (tap water, saline water and acidic solution). Various investigations such as setting time, compressive strength, scanning electron microscope (SEM), energy dispersive x-ray (EDX), X-ray diffraction (XRD) and potentiodynamic polarization studies were carried out. The setting time test confirmed that the NT acts as an accelerator. The 28 days-compressive strength of mortar increased with the addition of NT. The results of SEM and XRD analyses indicate that NT improved the microstructure and increased the amounts of desirable hydration products. The 360 days-compressive strengths of NT admixed mortar exposed under tap water, saline water and acidic solution were found to be higher than control mortar. The corrosion inhibition efficiency of NT was observed to be increasing with the increase in the dosage, in all the exposure environments.

Career Choices and Preferences of Saudi Pharmacy Undergraduates: A Cross Sectional Study

Despite the increasing number of pharmacy schools and their graduates, the healthcare workforce shortage has increased in Saudi Arabia's pharmacy sector, especially with the opening of new retail pharmacies, industries and pharmaceutical companies, which means that more pharmacist positions have been created with expanded working hours. However, very limited data are available regarding the views and preferences of pharmacy students regarding their future job choices in Saudi Arabia, which may create concerns for licensing organizations, employers and institutions and also gaps between what students want and the vacancies for pharmacists. Therefore, this study aims to identify pharmacy students' career choices and examine the factors that influence their choices across different pharmacy schools in Saudi via a cross-sectional survey.

Performance analysis of an evolutionary LM algorithm to model the load-settlement response of steel piles embedded in sandy soil

Facile synthesis of g-C3N4/CdWO4 with excellent photocatalytic performance for the degradation of Minocycline