Journals
2026 EN
Gholami Zeinab · Sarafraz Mansour · Jaberyani Leila
+2 more
This study aims to achieve the efficient removal of Direct Blue 86 (DB86) dye by iron- and manganese-doped NH 2 -ZIF-8 (Fe-Mn@NH 2 -ZIF-8) as an advanced adsorbent. The surface characteristics of Fe-Mn@NH 2 -ZIF-8 adsorbent were analysed using various techniques, including FESEM, FT-IR, EDX, and BET analysis. The BET analysis showed the type IV isotherm that indicates the mesoporous structure of Fe-Mn@NH 2 -ZIF-8. The total pore volume and BET specific surface area of Fe-Mn@NH 2 -ZIF-8 particles were found to be 0.017 cm 3 g −1 and 22.36 m 2 g −1 , respectively. In order to optimise operational parameters influencing the adsorption process, a series of experiments was designed based on response surface methodology (RSM) with central composite design (CCD). The high efficiency in removing DB86 using Fe-Mn@NH 2 -ZIF-8 was obtained at optimal conditions included an adsorbent dosage of 0.125 g L −1 , pH of 5, contact time of 92.5 minutes and dye concentration of 14 mg L −1 . The removal efficiency of the DB86 reached a maximum of 97.1%. The Freundlich isotherm generally represents multilayer adsorption occurring on heterogeneous surfaces, often characterised by differing affinities between the dye molecules and the functional groups of the adsorbent. The high predicted R 2 values obtained for the pseudo-second-order kinetic model indicated that this model best describes the adsorption kinetics of DB86 on the Fe-Mn@NH 2 -ZIF-8 adsorbent. In summary, Fe-Mn@NH 2 -ZIF-8 demonstrates the best significant potential for the removal of the dye and makes a promising option for wastewater treatment applications.
Journals
2026 EN
Hussein Zeinab M. · Ramadan Afaf A. · Eladawy Shereen A.
+1 more
The aim of this work was to formulate and develop LEV loaded nanospheres in situ nasal gel. This is an efficient therapy for epilepsy via brain targeting to increase bioavailability and reduce the dose frequency. This study looked at the impact of process factors (polymer amount (mg) (50,7 5, and 100), poloxamer 188 concentration (0.5, 1, and 1.5), and polymer type (Eudragit S100, Eudragit L100, and Eudragit RS 100)) on the responses (particle size (nm), entrapment efficiency (%), and zeta potential (mV) in order to optimize LEV-loaded nanospheres utilizing Box–Behnken design. The design expert software was used to perform the process of optimization categorically. Using the nanoprecipitation process, LEV-loaded nanospheres were effectively formulated, which were then evaluated by FTIR and DSC for drug-polymer interaction, TEM, zeta potential, and particle size. The optimized nanospheres formulation, which had the composition of 100 mg Eudragit S100 and 1.5% poloxamer 188, showed a particle size of 79.07 nm, % entrapment efficiency of 99.74%, and a zeta potential of −40.6 mV. DSC thermogram and FTIR spectrum showed no interaction between drug and polymer used. TEM image indicates spherical shape of the nanosphere formulation, LEV-loaded nanospheres in situ nasal gels were prepared using Na CMC at different concentrations (0.5, 1, and 1.5). NG3 (1.5% NaCMC) showed the best characterization of in situ nasal gel (gelation time of 18 s, gelation temperature of 28.6 °C and % drug release of 73%). In ex-vivo permeation study, the amount of LEV permeated from LVT loaded nanospheres in situ nasal gel (NG3) and the plain LVT in situ nasal gel were 75.5 and 67.8, respectively. NG3 confirmed higher permeability so it was chosen for in vivo pharmacokinetic study. It showed absolute bioavailability five folds greater than the IV route of administration. LEV-loaded nanospheres in situ nasal gels enhanced its tissue permeability and pass BBB directly which bypass the first pass metabolism in liver. So the bioavailability increases.
Journals
2026 EN
Eshaghi Alireza · Ebadati Erfan · Barzigar Amirhossein
+3 more
This study presents a comprehensive economic and life cycle analysis of a multi-energy system designed for the simultaneous generation of power, heat, cooling, and hydrogen in drying systems. The research evaluates the system’s performance by focusing on key economic indicators such as Levelized Cost of Energy (LCOE), Internal Rate of Return (IRR), and Discounted Payback Time (DPT), while also examining environmental impacts through life cycle assessment (LCA) metrics. Additionally, the study assesses water demand, global warming potential, and other environmental effects. Results indicate that the system provides significant advantages in terms of efficiency and environmental sustainability, with solar Direct Normal Irradiation (DNI) being a critical factor influencing the system’s economic performance. As the input temperature of the air turbine increases, the LCOE decreases to 0.0878 $/kWh, while the IRR reaches 27%. The liquid air storage tank (LAST) accounts for 25% of the total cost rate, making it the largest cost contributor. Sensitivity analysis reveals that higher DNI levels increase IRR and extend DPT, and they also cause a linear rise in LCOE, which reaches up to 0.0946 $/kWh. Overall, despite the relatively high initial investment, the integrated MES demonstrates strong long-term economic viability and notable reductions in environmental impacts, supporting its potential as a sustainable energy solution for future drying and industrial systems.
Journals
2026 EN
Jalambadani Zeinab · Mahmoudi Rahil · Assarzadeh Hossein
+2 more
This study aimed to determine the effect of mindfulness-based art therapy (MBAT) in improving breast cancer patients’ quality of life, lifestyle, and health literacy in Torbat Jam, Iran, in 2024. The participants of the present quasi-experimental study were 84 patients with breast cancer (42 patients in the intervention group and 42 patients in the control group). The findings showed that the MBAT group demonstrated significant improvements in key health-related aspects as measured by the Quality of Life Questionnaire (SF-36), Health Promoting Lifestyle Profile-II questionnaire, and Health Literacy Questionnaire. It was found that the MBAT intervention had a significant effect on improving lifestyle behaviors (p < .05). The findings indicate that the significance level for quality of life is .001 with an F value of 8.573; the significance level for lifestyle is .030 with an F value of 2.816; and the significance level for health literacy is .001 with an F value of 34.954. The effect sizes (partial η 2 ) for quality of life, healthy lifestyle, and health literacy are .732, .473, and .918, respectively, with the largest effect being for health literacy (.918) and the smallest for healthy lifestyle (.473). The observed differences between the participants’ average scores in the interventional and control groups in the posttest stage are significant with 95% confidence (p < .05). This investigation of MBAT provides initial encouraging data that support a possible future role for the intervention as a psychosocial option for improving the quality of life, lifestyle, and health literacy of breast cancer patients.
Journals
2026 EN
Karimi Zeinab · Tabibi Hadi · Nafar Mohsen
+4 more
Increased intestinal permeability resulting from gut dysbiosis, cardiovascular disease (CVD), and graft failure is common among kidney transplant (KT) recipients. This study was designed to investigate the effects of synbiotics on intestinal permeability, systemic and vascular inflammation markers, oxidative stress, and fibrosis in KT recipients. In this randomized controlled trial, 46 KT recipients were randomly assigned to either the synbiotic or the placebo group. Participants in the synbiotic group received two synbiotic capsules for 12 weeks, while the placebo group received a corresponding placebo. Serum lipopolysaccharide binding protein (LBP), interleukin-6 (IL-6), high-sensitivity C-reactive protein (hs-CRP), soluble intercellular adhesion molecule type 1 (sICAM-1), malondialdehyde (MDA), galectin-3, urea, and creatinine were measured. Serum LBP ( p = 0.03), hs-CRP ( p = 0.02), ICAM-1 ( p = 0.04), and IL-6 ( p = 0.02) showed significant reductions in the synbiotic group compared to the placebo group. Serum MDA, galectin-3, urea, and creatinine did not show significant changes within each group. This study indicates that synbiotics reduce LBP, a marker of intestinal permeability, as well as hs-CRP, IL-6, and sICAM-1, which are risk factors for CVD and graft failure, in KT recipients.
Resource
2026 EN
Orooji Niloufar · Ahmadi Fatemeh · Javadivala Zeinab
+2 more
Rheumatoid arthritis (RA) is a chronic inflammatory disease that can cause serious joint destruction if not properly managed. Despite established treatments, many patients struggle to find meaningful relief, emphasizing the need for new treatments. Galantamine (GAL), a naturally occurring alkaloid and acetylcholinesterase inhibitor with anti-inflammatory effects, has showed promise in preclinical RA research. This systematic review assessed GAL’s potential in RA by searching PubMed, Scopus, ISI Web of Science, and Google Scholar until June 2025, with no language or date restrictions. We omitted review articles, conference abstracts, book chapters, and studies that combined GAL with other substances or diseases. There was no human or in vitro research found, so seven eligible animal studies were analyzed. Evidence suggests that GAL improves RA outcomes by lowering inflammation and oxidative stress, blocking angiogenesis, and exhibiting anti-arthritic effects. These findings imply that GAL could be an effective treatment for RA. However, the available evidence is limited to animal models, and well-designed clinical trials are required to prove its efficacy and safety in people. This review emphasizes GAL’s therapeutic potential as well as the critical need for translational research to bridge the gap between preclinical and clinical applications.
Journals
2026 EN
Ahram Mamoun · Abdelhafiz Ahmed Samir · Mohammed Zeinab
+4 more
Researchers in low- and middle-income countries (LMICs) confront multifactorial challenges when publishing their manuscripts. Here, we aimed to quantify Arab researchers’ perceptions of these challenges. We distributed an online questionnaire to Arab researchers from 17 countries, the majority of which were LMICs. Among 286 respondents, 71.7% experienced rejection of at least one manuscript. The main reasons for manuscript rejection included being outside the journals’ scopes (46.1%) and lacking novelty (35.1%). Over one-third of the respondents believed they might have faced bias in the review process being of Arab origin. More than 60% thought a Western coauthor would make their manuscripts be reviewed more favorably. Moreover, 60% thought it would be easier to publish in open-access journals. Over 75% of our respondents were aware of predatory journals, and an alarming 17.1% published in such journals. To improve the quality of scholarly publications and address publishing challenges, we propose strengthening research training, enhancing language support, and increasing the representation of LMIC researchers in editorial roles. These measures aim to foster inclusivity in peer review and ensure a more diverse academic publishing landscape.
Journals
2026 EN
Hosseinzadeh-Posti Mohammad · Kamal Zeinab · Rajaeirad Mohadese
This study aimed to elucidate the vertebral bone density variations associated with adolescent idiopathic scoliosis (AIS), specifically examining the impact of unilateral muscle paralysis using an integrated approach combining Frost’s Mechanostat theory, a three-dimensional subject-specific finite element model and a musculoskeletal model of the L2 vertebra. The findings revealed a spectrum of bone density values ranging from 0.29 to 0.31 g/cm3, along with vertebral micro-strain levels spanning from 300 to 2200, consistent with existing literature. Furthermore, the ratio of maximum von Mises stress between the concave and convex side in the AIS model with intact muscles was approximately 1.08, which decreased by 4% due following unilateral paralysis of longissimus thoracis pars thoracic muscle. Overall, this investigation contributes to a deeper understanding of AIS biomechanics and lays the groundwork for future research endeavors aimed at optimizing clinical management approaches for individuals with this condition.
Resource
2026 EN
Gasavi Nezhad Zeinab · Gard Steven A. · Arazpour Mokhtar
Hyperkyphosis, defined as excessive forward thoracic curvature, is associated with pain, impaired balance, increased fall risk, and reduced quality of life in older adults. Spinal orthoses have been proposed as a therapeutic option. This systematic review evaluated their effects on pain, kyphosis angle, balance, fall risk, and quality of life. The protocol was registered in PROSPERO (CRD42024607584) and followed PRISMA 2020 guidelines. Comprehensive searches of PubMed, Web of Science, Scopus, CINAHL, and Cochrane Library up to November 2024 identified 16 eligible studies involving 757 participants and 13 orthosis types. Inclusion criteria covered clinical trials, cohort, cross-sectional, and observational studies in adults ≥60 years with hyperkyphosis, while surgical, pharmacological, and non-hyperkyphotic studies were excluded. Data were synthesized qualitatively, with balance outcomes classified as static or dynamic, and orthoses categorized by design and function. Risk of bias was assessed using PEDro and ROBINS-I. Findings suggest spinal orthoses, particularly semi-rigid devices, may reduce kyphosis angle, alleviate pain, enhance balance, and improve quality of life. Nonetheless, heterogeneity, limited blinding, and non-randomized designs reduce certainty. Further high-quality trials are warranted to strengthen evidence. No funding was received.
Journals
2026 EN
Alizadeh Zeinab · Yazdandoost Hamedani Erfan · Jalilzadeh Afrooz
In this paper, we address variational inequalities (VIs) with a finite-sum structure. We introduce a novel and unified stochastic variance-reduced algorithm, utilizing the Bregman distance function, that can be applied to both monotone and non-monotone settings. We establish optimal convergence guarantees under the monotone case. For the non-monotone setting, we explore a structured class of problems that exhibit weak Minty solutions and analyse the complexity of our method, demonstrating improvements over existing approaches. Numerical experiments are provided to showcase the superior performance of our algorithm compared to state-of-the-art methods.