Journals
2026 EN
Tian Man-Wen · Mao Jun-Bo · Mohammadiyan Behrooz
+2 more
This paper presents a K-dimensional system of an anti-periodic boundary value problem for nonlinear fractional differential equations with Riemann–Liouville–Caputo derivatives. Here, we will study inequalities such as the new fractional Grunwald and several fixed point theorems, as well as some results on the existence of solutions that Lipschitz holds. In the examples section, we had three examples that will group the results obtained for a specific two-dimensional case in a table and draw their graphs to better display the relationships and results. We also discussed the existence and uniqueness of a system of fractional differential equations to model a financial problem. In fact, by applying Caputo's fractional derivative, we have obtained a new financial model.
Journals
2026 EN
Nabil Rowa
Yawmiyyāt al-Wāḥāt [Al-Wahat Diaries] is the diaries Sonallah Ibrahim (1937–2025) kept between April 1962 and April 1964 while serving a politically-motivated prison sentence. This paper advances the existing scholarship by offering a close reading of the diary entries, drawing upon epitextual material that has not previously been considered in studies of Sonallah Ibrahim’s work. The first section examines how the experience of politically motivated imprisonment infringes on the practice of diary writing, arguing that the diaries constitute both the site and the textual artefact of Ibrahim’s subversive labour in the face of a precarious existence. The second section addresses questions of genre identity and readerly expectations by engaging with Ibrahim’s prison diaries in relation to the diary in the Arabic tradition. This section advances existing knowledge on the diary in the Arabic-speaking world by presenting a novel overview of Arabic diary studies, which could be a useful alternative to drawing upon the European tradition when studying diaries in non-European contexts. The final section analyses Ibrahim’s editorial interventions for publication as means of articulating the multiple layers of silence embedded in the prison diaries.
Journals
2026 EN
Bilkay Halil İbrahim · Erdoğan Esra · Usta Abdullah
The issue of low adherence, persistence, and continuation rates, coupled with high dropout rates, represents a significant challenge in the field of addiction treatment. It is therefore of paramount importance to gain an understanding of the underlying causes of treatment discontinuation. The objective of this study was to examine the experiences of individuals who were treated in an inpatient clinic for addiction in Türkiye and subsequently discontinued their treatment. In order to ascertain the reasons behind the decision to terminate 21-day inpatient treatment, face-to-face interviews were conducted with six participants who had voluntarily discontinued their treatment between March and June 2022. A parallel mixed-methods approach was used to collect both qualitative and quantitative data. Findings revealed a prevalence of amphetamine derivative use among participants. Factors such as individual characteristics, environment, treatment protocols, and operational aspects influenced treatment outcomes. Participants exhibited high levels of addiction, which played a significant role in their decision to discontinue treatment. These findings can inform the development of more effective treatment protocols and support strategies to improve adherence and reduce dropout rates.
Journals
2026 EN
Mohamed Ebid Abdel-Hameed Ibrahim · Fahim Genina Yasmine Magdy · Shawky Haffez Hesham Raafat
+3 more
Palbociclib is a cornerstone treatment for patients with hormone receptor-positive and human epidermal growth factor receptor 2-negative, metastatic breast cancer. This retrospective cohort study included 140 patients who were resistant to endocrine therapy and received palbociclib in combination with endocrine therapy. It is aimed to evaluate the efficacy and tolerability of palbociclib and to identify factors influencing progression-free survival and overall survival. A total of 140 were enrolled in the study; 57 and 83 patients were primary and secondary resistance to endocrine therapy, respectively. In the whole cohort, regarding progression-free survival; low Ki-67 and incidence of moderate-to-severe (grade 3/4) neutropenia were associated with longer median progression-free survival with p -values of 0.004 (3.7 vs. 8.4 months) and 0.026 (4.7 vs. 6.5 months), respectively. Regarding overall survival, duration on palbociclib (≥12 months) had longer overall survival compared with patients who received palbociclib <12 months ( p = 0.0012). The overall survival was longer in the secondary-resistant group than in the primary-resistant group (log-rank test p = 0.0003). In a metastatic setting, low Ki-67 and moderate-to-severe neutropenia are associated with better survival outcomes in endocrine resistant patients treated with palbociclib (Clinical trial registration: www.clinicaltrials.gov identifier is NCT06338644).
Journals
2026 EN
Al Twahya Safa’ F. · Hijazeen Rima · Almomani Hamzeh
+2 more
The psychological aftermath of the COVID-19 pandemic and ongoing regional stressors have influenced mental health needs in Jordan. Understanding antidepressant utilization and expenditure trends is essential for improving treatment access and resource planning. A retrospective market analysis was conducted using national IQVIA sales data (2019–2023), standardized by the World Health Organization’s Defined Daily Dose methodology. Prescription-level data from Advanced Marketing Statistics (AMS) for 2021–2022 were analyzed to assess prescribing patterns by age, gender, and clinical indication. Descriptive and correlation analyses were performed. Antidepressant utilization in Jordan’s private sector increased steadily between 2019 and 2023, dominated by selective serotonin reuptake inhibitors (SSRIs), which comprised 79% of total use. Escitalopram was most prescribed (40%), followed by sertraline (18.9%) and citalopram (3.3%). Prescriptions were more frequent among males (55.6%) and adults aged 30–54 years. Major depressive disorder accounted for 46.7% of indications. Fluoxetine use was higher among females, while tricyclic antidepressants were more common in males. SSRIs, particularly escitalopram, dominate antidepressant prescribing in Jordan’s private sector. Patterns vary by age and gender, reflecting clinical diversity. Findings highlight the growing economic burden of antidepressants and the need for cost-containment and targeted mental health strategies.
Journals
2026 EN
Holdback Connor J. M. · Kelso Richard M. · Haydon David S.
+3 more
The use of a throwing pole in seated shot put is prevalent across many athletes with varying impairment types in para-athletics and it has been shown to have a large impact on throwing technique. However, the measurement of throwing pole forces in seated shot put has not been reported previously in the research literature, leading to a considerable barrier to a better understanding and optimisation of performance. In this research, the first set of pole force measurements in seated throwing is presented, along with a comparison between two methods for such measurement: a direct load-sensing and a deflection-based method, where the latter requires considerably less specialised equipment than the former. From this, the measurement of pole forces without an instrumented pole is found to be feasible (RMSE < 10%), thus providing a simpler option for the measurement of pole forces in seated throwing. In addition, unexpected resonant pole effects (5–6 Hz) are observed during the throw which may have an interaction with the way athletes apply force to the pole. The methods and findings presented are intended to provide a platform for future research.
Journals
2026 EN
Yıldırım Mem Arjen · Kurkut Bülent · Boza Barış
+1 more
To evaluate the feasibility and safety of performing myomectomy during cesarean delivery using a novel bleeding-reducing suture technique. This retrospective cohort study included pregnant women with intramural uterine fibroids. A total of 120 patients were divided into two groups: Group A consisted of women who underwent myomectomy during cesarean section between January 2020 and June 2024, and Group B included women who underwent cesarean section alone without myomectomy. The following data were obtained from hospital records and compared between the groups: maternal age, gravidity, parity, myoma size, gestational age at time, preoperative and postoperative hemoglobin (Hb) levels, need for blood transfusion, hospital stay, and duration of surgery. The primary outcome of the study was the change in Hb levels before and after the operation. The demographic and laboratory characteristics of 120 pregnant women with intramural leiomyomas who underwent either cesarean myomectomy or cesarean section alone were analyzed. Of these, 60 underwent cesarean section alone, while 60 underwent cesarean section with myomectomy. No statistically significant difference was found between the two groups in terms of preoperative Hb, postoperative 24-hour Hb, or Hb decrease ( p = .240, p = .270, and p = .420, respectively). Similarly, there was no significant difference in operation duration ( p = .160). A weak but statistically significant negative correlation was observed between myoma size and gestational age at delivery ( r = −0.21, p = .0009). No statistically significant correlations were found between myoma size and either operation time or hospital stay. Cesarean myomectomy appears to be a feasible and safe option when performed using the bleeding-reducing uterine isthmic circumferential suture technique. However, further multicenter studies with larger sample sizes are required to confirm these findings before recommending cesarean myomectomy as a routine approach.
Resource
2026 EN
Fastenrath Fabian · Sattler Katherine · Duerschmied Daniel
+3 more
Sudden cardiac death (SCD) remains a major cause of mortality despite substantial progress in heart failure management and arrhythmia prevention. Current implantable cardioverter-defibrillator (ICD) guideline recommendations, mainly based on left ventricular ejection fraction (LVEF), are largely derived from historical trials and may no longer reflect contemporary patient populations or therapies. This review critically appraises the historical and contemporary ICD evidence base with particular attention to evolving background therapy, competing risks of non-arrhythmic death, device technology, and modern risk stratification strategies. ICD trials cited in major international guidelines were reviewed and supplemented by a targeted PubMed literature search using ICD-related keywords, including relevant publications through September 2025. We emphasize emerging tools such as cardiac magnetic-resonance-imaging, genomics, artificial intelligence, remote monitoring data, and modular cardiac rhythm management systems. We propose a future ICD trial framework grounded in multimodal risk assessment, competing-risk-adjusted endpoints, pragmatic and adaptive trial designs, and device-specific evaluation pathways. We further outline how future guidelines may evolve to incorporate enriched patient phenotyping, precision risk prediction, and personalized device selection. Together, these developments signal a paradigm shift toward an individualized, digitally supported, and modular approach to SCD prevention in the next decade.
Journals
2026 EN
Selim Ahmed A. M. A. · Ibrahim Marwa A.
Three isolated natural benzofuran compounds 1a-c and four semi-synthesized benzofuran derivatives 2a,b and 3a,b were evaluated for their in vitro acetylcholinesterase inhibition assay. Most of the tested compounds showed moderate activity with IC 50 ranged from 102.4 ± 5.72 µM to 565.75 ± 4.17 µM, the most potent compound was kellin 1a with IC 50 102.4 ± 5.72 µM. The kellin derivatives 1a, 2a and 3a bearing additional methoxyl group showed more inhibition activity than its analogues of visnagin derivatives 1b,c , 2b and 3b . The in silico investigation on the seven benzofuran derivatives matched our in vitro acetylcholinesterase results and explains the similarity in structures between the benzofuran compounds and donepezil drug. khellin had the best pharmacophore features among the studied compounds, the best fit score 1.862 and best dock score −9.135. In addition, our in silico study showed clearly that compounds carrying additional hydrophobic group had more potent activity through matched more ligand features.
Journals
2026 EN
Syed Mohamad Sharifah Nurul Akilah · Khatib Alfi · Mat So’ad Siti Zaiton
+10 more
Our earlier research demonstrated α-glucosidase inhibitory (AGI) and antioxidant activities of the optimised extract of Psychotria malayana leaves. It was reported having numerous compounds, although it was unclear which compounds exhibit the bioactivities as well as their binding interaction to the enzyme. This study aimed to identify the compounds possessing AGI and antioxidant activities in the extract utilising GC-MS-based metabolomics, and to analyse the ligand-enzyme binding interactions via in-silico molecular docking. A partial least square was employed to correlate the metabolite profile and bioactivities. The loading plot reveals the bioactive compounds in this extract. The AGI activity of 1-cyclohexene-1-carboxylic, propanoic, butanedioic and D-gluconic acid together with the antioxidant activity of some compounds were reported for the first time through this study. The docking study reveals that all compounds, except for 1-cyclohexene-1-carboxylic acid, exhibit binding to the enzyme’s catalytic site. This discovery demonstrates the potential of this plant for diabetes therapy.