Netlist-Independent Functional Stress Pattern Generation Strategy for AI HW Accelerators Embedded into SoCs

Artificial Intelligence hardware accelerators are pervading the chip market. Most of the time, they are third-party IPs integrated by silicon manufacturers. As a consequence, their design may be obfuscated, which can introduce issues from a manufacturing testing perspective. This paper illustrates how to effectively and efficiently select the most appropriate functional stress stimuli for Artificial Intelligence (AI) Hardware (HW) Accelerators embedded in System-on-Chip (SoC). The proposed methodology is netlist independent; and it is based on both current measurements from the real chip and architectural evaluations. These ingredients are heuristically used to rank and sift the optimal functional patterns to apply along the Burn-In (BI) phase. Experimental results on two different Automotive SoCs manufactured by STMicroelectronics, demonstrate the effectiveness and efficiency of the proposed method.

Grade 3 acute kidney injury caused anti‐glomerular basement membrane nephritis during immune checkpoint inhibitor treatment for melanoma

Potential thioflavin T false positives in lipomembranous changes in adipocytes during systemic amyloidosis diagnosis

Abstract The diagnosis of systemic amyloidosis relies on the detection of amyloid deposition in the tissue, often utilizing biopsy specimens from the abdominal skin owing to their minimal invasiveness. Several amyloid staining methods, including Congo Red, Direct Fast Scarlet (DFS), and Thioflavin T (ThT), have been employed for visualization. Lipomembranous fat necrosis (LFN) is a non‐specific reaction pattern of adipose tissue to injury, typically derived from blood insufficiency across a wide range of clinical conditions or diseases. It is characterized by the presence of eosinophilic, crenulated, and/or serpiginous membranes in fat lobules. We encountered a patient in whom ThT yielded suspiciously positive results in amyloidosis screening tests. Furthermore, our retrospective observations suggested that ThT staining was positive for LFN, whereas DFS and Congo red staining yielded negative results. The awareness that LFN can result in false‐positive ThT staining during amyloid screening is crucial to avoiding the misdiagnosis of systemic amyloidosis. Furthermore, skin samples should not be collected from areas prone to developing lipomembranous changes. The use of more than two different stains for skin biopsy specimens is recommended.

Malignant Transformation From Seborrheic Keratosis to Squamous Cell Carcinoma Is More Likely to Occur in Nonexposed Areas: A Single‐Center Retrospective Study

Pathogenesis of Pseudocheckerboard Pattern in Mechanic's Hands

ABSTRACT Among the relatively common manifestations of dermatomyositis (DM), “mechanic's hands” refer to symmetric hyperkeratotic erythematous lesions on the ulnar aspect of the thumbs and the radial aspect of the index and middle fingers. The “pseudocheckerboard pattern” is a distinct histopathological finding associated with mechanic's hands. This pattern consists of vertical keratotic columns in the stratum corneum, some of which display a striped appearance characterized by alternating bands of orthokeratosis and parakeratosis in both vertical and horizontal orientations. Although this phenomenon is well documented, its underlying mechanism remains poorly understood. In this study, we collected tissue samples from 14 patients with DM accompanied by mechanic's hands and reviewed their clinical presentations and histopathological features. We identified several common histopathological findings of DM, including the characteristic pseudocheckerboard pattern associated with these lesions. Parakeratotic foci of the pseudocheckerboard pattern were observed within the stratum corneum, corresponding to the suprapapillary epidermis, where both CD4‐ and CD8‐positive lymphocytes infiltrated the papillary dermis and suprapapillary epidermis. A portion of these lymphocytes expressed interleukin (IL)‐17, and the number of IL‐17‐positive cells was comparable to that in psoriatic skin lesions. The inflammatory response was relatively confined to the papillary dermis and suprapapillary epidermis, suggesting that Th17‐mediated epidermal hyperplasia may be involved in the pathogenesis of mechanic's hands.

A Case of Microinvasive Malignant Hidroacanthoma Simplex/Porocarcinoma With Folliculo‐Sebaceous Differentiation Only at Lymph Nodes Metastases With Absence of YAP1 , PAK1/2/3 Fusions

Adult‐Onset Xanthogranuloma Treated With a Combination of Oral Prednisolone and Methotrexate

Implementing sustainable practices to reduce wastage and costs in adenotonsillectomy

Abstract Background Surgical waste presents significant environmental and economic challenges in healthcare. Adenotonsillectomy, a common otolaryngological procedure, contributes to this issue. There is limited research on sustainability measures in adenotonsillectomy, and no studies have specifically identified waste reduction strategies for this operation in a general ENT unit. This study aimed to identify sustainable practices for waste reduction in adenotonsillectomy surgeries and quantify the extent of waste reduction in terms of weight and cost. Methods The items opened and waste produced during adenotonsillectomies in a single institution were documented, including weights and costs. After reviewing the actual materials used by otolaryngologists and identifying potentially avoidable waste, a low‐waste setup was designed. Waste weight and costs were evaluated post‐implementation and compared with baseline values. Results Several steps to reduce wastage in adenotonsillectomy surgeries were identified, including the elimination of surgical drapes and gowns. This resulted in a waste reduction of over 60%, with an average reduction in weight per case of 1.114 kg. The estimated reduction over 1 year for 294 cases was 327.52 kg. The mean reduction in material costs per case was $41.67, with an extrapolated annual savings of $12 250.98 for 294 cases. Conclusion Implementing sustainable practices in adenotonsillectomy surgeries can significantly reduce waste and healthcare facility cost, providing both environmental and economic benefits.

Combined Lyon and Milan Scores Predict Gerd Management Outcome Better Than Either Score Alone or Their Individual Components

ABSTRACT Background Confidence in gastro‐oesophageal reflux disease (GERD) diagnosis is crucial to improve outcomes from escalation of treatment. The Lyon score phenotypes patients through endoscopy and pH‐impedance (MII‐pH). The Milan score quantifies antireflux barrier through high‐resolution manometry (HRM) parameters. Aim To explore the relationship between the Lyon and Milan scores and their combined performance in predicting clinical outcomes. Methods We collected clinical and follow‐up data of consecutive patients with HRM and MII‐pH from nine centres. Clinical improvement was defined as a 50% reduction in global symptoms. The relationship between Lyon and Milan scores and the rate of patients improved in Lyon phenotypes and Milan categories were explored. The ability of the Lyon, Milan, DeMeester scores and acid exposure time (AET) in predicting outcomes was assessed through receiver operating characteristics (ROC) analysis. Results Among 532 patients (50.6% female, age 50 years), 47.7% had pathologic GERD. A stepwise increase in the Milan score in Lyon phenotypes was observed. Sixty‐three patients had surgical treatment, and 131 medical. Clinical improvement in Lyon phenotypes Conclusive and Severe was 81% and 83%; in Milan categories very likely and extremely likely was 88.5% and 100%. If Lyon and Milan scores were positive, improvement was 89%; if discordant, 63%; if both negative, 19% ( p  < 0.001). ROC analysis showed an AUC of 0.790 for Lyon score, 0.835 for Milan score, 0.736 for DeMeester score and 0.741 for AET. Conclusions The Lyon and Milan scores outperformed AET and DeMeester scores in predicting outcomes in GERD patients. When concordant, they provide optimal predictive accuracy, guiding escalation of therapy.

Fostering circular economy through open innovation: Insights from multiple case study

Abstract This study represents an empirical, comprehensive investigation of two different inter‐organisational collaborative approaches, offering a novel perspective on collaborative circular business models in the modern economy. In this vein, we explore how open innovation strategies foster the implementation of circular economy practices within a circular supply chain and a circular ecosystem. In addition, we identify and characterise stakeholders' roles in facilitating the translation of circular principles into a viable business. An inductive theorising approach was employed, leveraging an explorative multiple case study methodology. Data were collected from 13 organisations involved in two collaborative networks, designed to establish upcycling practices to recover waste from the food and beverage industry. A critical realist philosophical positioning underpinned researchers' data collection and analysis. As a result, we outline the nature of two different collaborative approaches to pursue a regenerative production system through open innovation strategies: a circular supply chain and a circular ecosystem architecture. The characterisation of the coordinator and orchestrator of collaborative circular business models is also highlighted in our findings. In sum, this study contributes to the literature on circular economy by unveiling the role of open innovation in fostering circular business development. From a practical standpoint, it offers insights for managers of sustainability‐oriented companies willing to implement upcycling practices.