Showing 336127–336140 of 336,781 results for "Steven Wishart"

Journals 2009 EN

Longitudinal Modeling of Age-Related Memory Decline and theAPOEε4 Effect

Richard J. Caselli · Amylou C. Dueck · David Osborne +12 more

The APOE epsilon4 allele is associated with the risk of late-onset Alzheimer's disease. The age at which memory decline diverges among persons who are homozygous for the APOE epsilon4 allele, those who are heterozygous for the allele, and noncarriers is unknown.

Massachusetts Medical Society
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Journals 2009 EN

Denosumab for Prevention of Fractures in Postmenopausal Women with Osteoporosis

Steven R. Cummings · Javier San Martín · Michael R. McClung +13 more

Denosumab is a fully human monoclonal antibody to the receptor activator of nuclear factor-kappaB ligand (RANKL) that blocks its binding to RANK, inhibiting the development and activity of osteoclasts, decreasing bone resorption, and increasing bone density. Given its unique actions, denosumab may be useful in the treatment of osteoporosis.

Massachusetts Medical Society
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Journals 2009 EN

Early versus Delayed, Provisional Eptifibatide in Acute Coronary Syndromes

Robert P. Giugliano · Jennifer A. White · Christoph Bode +14 more

Glycoprotein IIb/IIIa inhibitors are indicated in patients with acute coronary syndromes who are undergoing an invasive procedure. The optimal timing of the initiation of such therapy is unknown.

Massachusetts Medical Society
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Journals 2009 EN

Antibiotic Prophylaxis and Recurrent Urinary Tract Infection in Children

Jonathan C. Craig · Judy M. Simpson · Gabrielle Williams +11 more

Antibiotics are widely administered to children with the intention of preventing urinary tract infection, but adequately powered, placebo-controlled trials regarding efficacy are lacking. This study from four Australian centers examined whether low-dose, continuous oral antibiotic therapy prevents urinary tract infection in predisposed children.

Massachusetts Medical Society
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Journals 2009 EN

Mutation ofFOXL2in Granulosa-Cell Tumors of the Ovary

Sohrab P. Shah · Martin Köbel · Janine Senz +38 more

Granulosa-cell tumors (GCTs) are the most common type of malignant ovarian sex cord-stromal tumor (SCST). The pathogenesis of these tumors is unknown. Moreover, their histopathological diagnosis can be challenging, and there is no curative treatment beyond surgery.

Massachusetts Medical Society
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Journals 2009 EN

MMP12,Lung Function, and COPD in High-Risk Populations

Gary M. Hunninghake · Michael H. Cho · Yohannes Tesfaigzi +23 more

Genetic variants influencing lung function in children and adults may ultimately lead to the development of chronic obstructive pulmonary disease (COPD), particularly in high-risk groups.

Massachusetts Medical Society
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Journals 2009 EN

Combined Immunodeficiency Associated withDOCK8Mutations

Qian Zhang · Jeremiah C. Davis · Ian T. Lamborn +9 more

Recurrent sinopulmonary and cutaneous viral infections with elevated serum levels of IgE are features of some variants of combined immunodeficiency. The genetic causes of these variants are unknown.

Massachusetts Medical Society
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Journals 2009 EN

Cardiac-Resynchronization Therapy for the Prevention of Heart-Failure Events

Arthur J. Moss · William J. Hall · David S. Cannom +11 more

This trial was designed to determine whether cardiac-resynchronization therapy (CRT) with biventricular pacing would reduce the risk of death or heart-failure events in patients with mild cardiac symptoms, a reduced ejection fraction, and a wide QRS complex.

Massachusetts Medical Society
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Journals 2009 EN

Platelet Inhibition with Cangrelor in Patients Undergoing PCI

Robert A. Harrington · Gregg W. Stone · Steven E. McNulty +17 more

Cangrelor, a nonthienopyridine adenosine triphosphate analogue, is an intravenous blocker of the adenosine diphosphate receptor P2Y(12). This agent might have a role in the treatment of patients who require rapid, predictable, and profound but reversible platelet inhibition.

Massachusetts Medical Society
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