Journals
2025 EN
Eng Moore Tiffany · Moriarty Maeve · Barnes Stephanie
+3 more
This paper reviews a collaborative examination and analysis of an early nineteenth-century music manuscript at the Canadian Conservation Institute. Collaboration between conservation scientists and conservators helped process scientific information, hazards, and treatment decisions to complete the arc of planning, treatment execution, and future care recommendations for the client. An unexpected result during the initial analysis of the pigments flagged the presence of arsenic on the painted and unpainted areas of the textblock. Initial hypotheses were that it could have derived from an application of pesticide on the binding or that it was part of the papermaking process. To characterize the nature of the arsenic more fully and to attempt to understand the level of risk during handling, further analysis was carried out. Through the analysis, it was determined that the source of arsenic in the manuscript is smalt – a blue glassy colourant, added to the paper during manufacture to make it appear whiter; there was no indication of an arsenical pesticide found. This case study provoked interesting discussions regarding the contextualizing of risk and analysis results when working with an unexpected finding of potential hazards, both during the execution of a conservation treatment, and in recommending care during handling and storage.
Journals
2025 EN
Nocoń Kamila
Thin-walled cooking pottery represents a distinctive category of ceramic material linked to culinary practices in the Eastern Mediterranean during the Roman period. Archaeological evidence has identified its production centres in regions such as Cyprus, the Levant and Syria. This study focuses on one of the groups of thin-walled cooking pottery recovered from the Agora in Nea Paphos, Cyprus. A macroscopic analysis of the assemblage reveals a standardized production process, with manufacturing dated to the 6th and 7th centuries CE. The homogenous fabric composition observed across the samples suggested a shared source of the raw materials, most likely originating from southern Asia Minor. Cilicia is proposed as a key centre for both the manufacturing and distribution of these ceramics, reflecting its strategic role in regional trade and cultural exchange. The findings from the Agora in Nea Paphos indicate that the production and distribution of this group of thin-walled cooking pottery were closely tied to intensified inter-regional interactions between south-western Cyprus and the southern coastline of Asia Minor during this period.
Journals
2025 EN
Venus Philine · Henniges Ute · Brückle Irene
+6 more
Ammonium citrate was introduced to paper conservation as an additive for what might be called “enhanced” washing, viewed as a more powerful brightening agent than washing alone and less aggressive than bleaching. We tested its effect on cellulose using two historical papers and one filter paper immersed in solutions of ammonium citrate (pH 5.5; pH 8.5), citric acid (pH 1.8), and ammonium and calcium hydroxide (both at pH 9.0). One set of papers was washed exclusively in these solutions, a second set subsequently received an alkaline reserve. We determined the CIE L*a*b* values for all samples before and after accelerated aging to capture color changes, and a selection of 36 samples underwent molar mass determination. Testing revealed differences between the samples treated with citric acid and ammonium citrate compared to the other treatment solutions: both historical papers brightened and maintained their brightness after accelerated aging. Molar mass data indicate that deacidification following the treatments helped to maintain the cellulose integrity of the tested papers during accelerated aging. Our findings indicate that the application of ammonium citrate may be considered as a washing additive if the treatment solution is thoroughly rinsed, and an alkaline reserve is added using calcium hydrogen carbonate.
Journals
2025 EN
Radlińska Kamila
In the traditional approach, labor underutilization are equated with unemployment, and its size is determined by the number of unemployed or the unemployment rate. Currently, however, this concept is beginning to be interpreted much more broadly. Because employees can also be a source of labor underutilization in enterprises. The main aim of the article is to analyze and evaluate the theoretical concept of labor underutilization. There are different theoretical approaches to explaining the emerging labor underutilization in enterprises. Sources of labor underutilization can be time-related underemployment, the mismatch skills and labor demand and the need to labor hoarding during economic slowdown. Each of them is guided by separate assumptions and research questions, but ultimately they create theoretical concept of labor underutilization.
Journals
2025 EN
Oliveira Kamila de Sá · Kharaghani Abdolreza · Tsotsas Evangelos
+2 more
Microencapsulation by spray drying is widely utilized for preserving and stabilizing essential fatty acids and functional oils. Recent studies have demonstrated that both flow rate and thermodynamic properties of drying air, along with the flow rate and composition of the emulsion, directly impact the quality of microparticles. In this work, a single droplet drying device was used to quantitatively establish the drying behavior of emulsions containing functional oil and typical encapsulating agents—gum arabic, modified starch, and maltodextrin. The drying kinetics of single emulsion droplets were measured at drying temperatures from 80 to 120ºC, and evaluated using the characteristic drying curves (CDC) approach. To investigate particle morphology and assess the size distribution of oil droplets on their surfaces, as well as the surface area fraction covered by oil, confocal laser scanning microscopy was utilized. The physicochemical properties of encapsulants and the transport phenomena underlying the drying kinetics data were thoroughly discussed, highlighting their implications for encapsulation efficiency and microparticle quality. Additionally, the CDCs were modeled with temperature-dependent functions, which can be further implemented in computational simulations. Overall, this research provides valuable insights for the design and optimization of spray drying microencapsulation processes for lipids.
Resource
2025 EN
Stepinska Paulina · Zawadzinska-Halat Kamila · Pastuszczak Maciej
Dupilumab has revolutionized treatment of moderate-to-severe atopic dermatitis (AD). However, its use has been associated with ophthalmologic adverse events referred to as dupilumab-associated ocular surface disease (DAOSD), reported in up to 30% of patients. Although several risk factors have been proposed, the role of Demodex folliculorum remains poorly defined. To evaluate the association between eyelid Demodex infestation and DAOSD development during the first 16 weeks of dupilumab therapy. This prospective study enrolled 30 adults with moderate-to-severe AD initiating dupilumab. All patients underwent ophthalmologic evaluation, Ocular Surface Disease Index (OSDI) scoring, Schirmer testing, conjunctival cultures, and Demodex detection. Follow-up was performed at 16 weeks. Patients were stratified by DAOSD status. DAOSD developed in 33% ( n = 10), presenting as blepharoconjunctivitis. Baseline Demodex infestation was significantly more frequent in the DAOSD group (70.0% vs. 5.0%; p = .0004; OR = 44.3). Baseline Eczema Area and Severity Index (EASI) scores, IgE levels, and Schirmer results did not differ. Post-treatment OSDI scores were higher in DAOSD patients (median 37.5 vs. 4.6; p = .0001). Bacterial cultures were not associated with DAOSD. Eyelid Demodex infestation is strongly associated with DAOSD development. Pretreatment screening may identify high-risk individuals. As most cases occur within 16 weeks, this study focused on the early treatment phase.
Journals
2025 EN
Soares Naís Lira · Cavalcante Hassler Clementino · Ferreira Soniellson de Lima
+7 more
Different intermittent fasting (IF) regimens have been used in healthy individuals to improve body composition; however, other potential benefits or harm, such as modulation of behaviours, are little studied in healthy populations. The present study aimed to evaluate the influence of different IF regimens on parameters related to the behavioural and cerebral aspects in healthy rats and compare them to caloric restriction. Adult Wistar rats were randomised into five groups: control (CON); caloric restriction (CR); time-restricted feeding (TRF); alternate-day fasting (ADF); and alternate-day modified fasting (ADMF), and then evaluated during four weeks. The ADF and ADMF groups had the lowest weight over the weeks and decreased depressive-like behaviour, while TRF decreased anxiety-like behaviour. However, all experimental groups presented some damage in the brain tissues (central cortex and hippocampus), and ADF had the largest area of NF-κB marking. Although all groups submitted to IF showed benefits in behaviour, they also presented damage to brain tissues (gemistocystic astrocytes, and ischemic neuronal cell bodies).
Journals
2025 EN
Fernandes Siqueira Maria Fernanda · Bezerra Massaut Khadija · da Cunha Kamila Furtado
+7 more
This study aims to characterize the chemical composition and evaluate the antimicrobial and antioxidant activities of Essential Oils (EOs) from the peel of different citrus species at two stages of maturation. The EOs were extracted by hydrodistillation, the composition of the EOs was determined by gas chromatography, the antimicrobial activity was evaluated by the agar diffusion method for bacteria and fungi, and the antioxidant activity was evaluated by the DPPH method. As a result, D-limonene was identified as the main compound in all EOs (57.13−87.1%), followed by γ-terpinene (10.69−20.79%) for two of the three species used in this study, at the two different stages of maturation. In general, all EOs evaluated presented interesting biological activities, for antioxidant activity (21.7% to 41.07%), antimicrobial activity (9 mm to 14 mm) and antifungal activity (7 mm to 15 mm), indicating that EOs from different citrus species at different stages of maturation have interesting potential for industrial applications.
Journals
2025 EN
Vodicka Prokop · Masar Michal · Benesova Katerina
+11 more
Symptoms of lymphomas include peripheral lymphadenopathy, B-symptoms, and other organ-specific symptoms; however, data on initial symptoms incidence in diffuse large B-cell lymphoma (DLBCL) remain limited. We aimed to investigate real-world patterns of initial DLBCL symptoms, correlating them with baseline characteristics and symptom onset-to-diagnosis interval. Patients with DLBCL diagnosed between 2010 and 2021 receiving R-CHOP were screened. 706 individuals with reported initial symptoms were analyzed. 682 (97%) patients had documented symptoms; remaining 24 patients (3%) had incidental findings discovered during examinations for unrelated reasons. Abdominal/gastrointestinal complaints were the most prevalent symptoms (26%), followed by peripheral lymphadenopathy (22%), and B-symptoms (13%). The median symptom-to-diagnosis interval was 10 weeks. Peripheral lymphadenopathy and testicular tumors correlated with low-risk characteristics, with testicular DLBCL featuring a shorter symptom-to-diagnosis interval. Limb pain/swelling and back pain were associated with high-risk characteristics and prolonged symptom-to-diagnosis interval. This analysis enhances our understanding of DLBCL symptomatology, aiding in timely recognition and management.
Journals
2025 EN
Kamila Manoj Kumar · Jasrotia Sahil Singh
In the contemporary business landscape, long-term marketing strategies depend significantly on ethical considerations with marketing components (4Ps). Despite the increasing interest and evolving discourse of marketing ethics, adopting ethical principles remains challenging for many corporations. Addressing this gap, our study conducts a bibliometric analysis to organize existing knowledge and highlight potential future research directions. By examining citation analysis and co-citation networks, we acknowledge the pivotal contributions of authors and organizations shaping the field. Employing cluster analysis, we identify eight key clusters within the marketing ethics literature. Our research not only consolidates valuable insights from prior literature but also serves to navigate future research in the realm of ethics in marketing.