Design and Implementation of MCNN for Better Prediction of Stock Price Movement

The stock market prediction is problematic subsequently the stock price is active in environment. To decrease the inappropriate predictions of the stock market and evolution the ability to predict the market actions. To escape the risk and the challenging in predicting stock price. Predicting stock market prices is a difficult task that conventionally contains extensive neural network. Owed to the linked environment of stock prices, conventional batch processing technique cannot be developed competently for stock market analysis. We propose an efficient Learning algorithm that develops a kind of Modified Computational Neural Networks (MCNN) based on BPNN (Back Propagation neural network) filter in training to increase the stock price prediction. Where the weights are adjusted for separate data points using stochastic gradient descent. This will distribute extra precise outcomes when linked to existing stock price prediction algorithms. The network is trained and evaluated for accurateness complete numerous sizes of data, and the results are organized.

Minimum Degree and Size Conditions for Hamiltonian and Traceable Graphs

A graph is called Hamiltonian (resp. traceable) if the graph has a Hamiltonian cycle (resp. path), a cycle (resp. path) containing all the vertices of the graph. In this note, we present sufficient conditions involving minimum degree and size for Hamiltonian and traceable graphs. One of the sufficient conditions strengthens the result obtained by Nikoghosyan in [1].

Sasadu Sebagai Simbol, Identitas Budaya dan Perekat Suku Sahu Di Kabupaten Halmahera Barat Provinsi Maluku Utara

Komunikasi manusia dan budaya tidak dapat dipisahkan atau dapat dikatakan bahwa komunikasi adalah kebudayaan dan kebudayaan adalah komunikasi. Komunikasi non verbal berupa simbol budaya dapat berbentuk gerakan, pakaian, objek, bendera, ikon  keagamaan dan sebagainya. Aspek simbolis yang penting dari budaya adalah bahasa penggunaan katakata untuk mewakili benda dan pandangan. Penyimbolan memungkinkan suatu budaya disampaikan dari generasi ke generasi. Tujuan penulisan makalah ini adalah untuk menjelaskan makna simbol pada Sasadu (Rumah Adat Suku Sahu) yang telah menjadi identitas budaya Suku Sahu di Kabupaten Halmahera Barat Provinsi Maluku Utara. Metode yang digunakan yaitu : melakukan kajian literatur yang relevan dari jurnal ilmiah, hasil penelitian, buku dan data sekunder yang relevan dengan topik penulisan makalah, kemudian dianalisis dan dijelaskan secara deskriptif. Hasil pembahasan makalah menyimpulkan bahwa makna simbol dan identitas budaya pada Sasadu Suku Sahu di Kabupaten Halmahera Barat yaitu: Sasadu merupakan Rumah Bersama Suku Sahu, Sasadu Sebagai Alat Perekat Suku Sahu dan Sasadu Sebagai Simbol Otoritas Fungsi Integratif, Nilai-nilai Hukum dan Etika Sosial Budaya Suku Sahu.

IMPACT OF ENVIRONMENTAL VARIABLES ON SPORE DISPERSAL TREND OF FUSARIUM MANGIFERAE CAUSING MANGO MALFORMATION DISEASE IN PAKISTAN

Malformation is one of the most destructive mango diseases. Although trees are not killed, the vegetative phase of the disease impedes canopy development during vegetative phase of the host plant and floral phase dramatically reduces fruit yield with overwintering inoculums during dormant phase of the host plant. Environmental conditions and trend of spore liberation of its pathogenic fungus “Fusarium mangiferae” were recorded during flowering phase (Feb-April, 2014), fruit development phase (May-July, 2014), vegetative phase (Aug-Oct, 2014), and dormant phase (Nov-Jan, 2014-15), of the mango plants. Through installation of spore traps of various distance levels containing Nash-Synder media in petri plates. During these phases, different environmental variables including temperature (T), relative humidity (R.H) and wind speed (W.S) were observed. Maximum number of colonies were observed through the spores trapped from the centre of the experimental block (0m) while minimum numbers of colonies were developed from the spores trapped at 150 m distance. Amongst different phenological phases of mango, fruit development remained very much contaminated with spores of the fungus while minimum spore liberation was noted during flowering phase of mango indicating very rare infection during this phase. This study also reflected that maximum number of airborne macro conidia of F. mangiferae were recorded when R.H was below 55%. Low R.H appeared to be a major factor associated with the diurnal conidial dispersal of airborne pathogen. Hence primary infection of F. mangiferae starts from vegetative and floral buds differentiation and control strategy including spray of systemic fungicides should start at this stage of development.

ir-HSP: Improved Recognition of Heat Shock Proteins, Their Families and Sub-types Based On g-Spaced Di-peptide Features and Support Vector Machine

STAT3-Mediated Transcriptional Regulation of Osteopontin in STAT3 Loss-of-Function Related Hyper IgE Syndrome

Background Hyper-IgE syndrome (HIES) caused by loss-of-function (LOF) mutations in STAT3 gene (STAT3 LOF HIES) is associated with dental and facial abnormalities in addition to immunological defects. The role of STAT3 in the pathogenesis of the dental/facial features is, however, poorly elucidated. Objectives Since mechanism of cellular resorption of mineralized tissues such as bone and teeth are similar, we attempted to study the expression of genes involved in bone homeostasis in STAT3 LOF HIES. Methods Peripheral blood mononuclear cells from healthy controls (HCs), STAT3 LOF HIES patients, STAT3 −/− PC-3 cells and STAT3 +/+ LNCaP cells were stimulated with IL-6 and quantitative PCR array was performed to study the relative mRNA expression of 43 pre-selected genes. PCR array finding were further evaluated after stattic induced STAT3 inhibition. Results Osteopontin (OPN) gene was seen to be significantly upregulated after IL-6 stimulation in HC (mean fold change 18.6, p  = 0.01) compared with HIES subjects. Inhibition of STAT3 signaling by stattic followed by IL-6 stimulation abrogated the OPN response in HCs suggesting that IL-6-induced STAT3 signaling regulates OPN expression. Bioinformatics analysis predicted the presence of STAT3 response element TTCCAAGAA at position -2005 of the OPN gene. Conclusion Regulation of OPN gene through IL-6-mediated STAT3 activation and its significant dysregulation in STAT3 LOF HIES subjects could make OPN a plausible candidate involved in the pathogenesis of dental/facial manifestations in HIES.

The Chlamydia M278 Major Outer Membrane Peptide Encapsulated in the Poly(lactic acid)-Poly(ethylene glycol) Nanoparticulate Self-Adjuvanting Delivery System Protects Mice Against a Chlamydia muridarum Genital Tract Challenge by Stimulating Robust Systemic and Local Mucosal Immune Responses

Recently, we reported that our PPM chlamydial nanovaccine [a biodegradable co-polymeric PLA-PEG (poly(lactic acid)-poly(ethylene glycol))-encapsulated M278 peptide (derived from the major outer membrane protein (MOMP) of Chlamydia )] exploits the caveolin-mediated endocytosis pathway for endosomal processing and MHC class II presentation to immune-potentiate Chlamydia -specific CD4 + T-cell immune effector responses. In the present study, we employed the Chlamydia muridarum mouse infection model to evaluate the protective efficacy of PPM against a genital tract challenge. Our results show that mice immunized with PPM were significantly protected against a homologous genital tract challenge evidently by reduced vaginal bacterial loads. Protection of mice correlated with enhanced Chlamydia -specific adaptive immune responses predominated by IFN-γ along with CD4 + T-cells proliferation and their differentiation to CD4 + memory (CD44 high CD62L high ) and effector (CD44 high CD62L low ) T-cell phenotypes. We observed the elevation of M278- and MOMP-specific serum antibodies with high avidity in the ascending order IgG1 > IgG2b > IgG2a. A key finding was the elevated mucosal IgG1 and IgA antibody titers followed by an increase in MOMP-specific IgA after the challenge. The Th1/Th2 antibody titer ratios (IgG2a/IgG1 and IgG2b/IgG1) revealed that PPM evoked a Th2-directed response, which skewed to a Th1-dominated antibody response after the bacterial challenge of mice. In addition, PPM immune sera neutralized the infectivity of C. muridarum in McCoy cells, suggesting the triggering of functional neutralizing antibodies. Herein, we reveal for the first time that subcutaneous immunization with the self-adjuvanting biodegradable co-polymeric PPM nanovaccine immune-potentiated robust CD4 + T cell-mediated immune effector responses; a mixed Th1 and Th2 antibody response and local mucosal IgA to protect mice against a chlamydial genital tract challenge.

Dysregulated miRNAome and Proteome of PPRV Infected Goat PBMCs Reveal a Coordinated Immune Response

In this study, the miRNAome and proteome of virulent Peste des petits ruminants virus (PPRV) infected goat peripheral blood mononuclear cells (PBMCs) were analyzed. The identified differentially expressed miRNAs (DEmiRNAs) were found to govern genes that modulate immune response based on the proteome data. The top 10 significantly enriched immune response processes were found to be governed by 98 genes. The top 10 DEmiRNAs governing these 98 genes were identified based on the number of genes governed by them. Out of these 10 DEmiRNAs, 7 were upregulated, and 3 were downregulated. These include miR-664, miR-2311, miR-2897, miR-484, miR-2440, miR-3533, miR-574, miR-210, miR-21-5p, and miR-30. miR-664 and miR-484 with proviral and antiviral activities, respectively, were upregulated in PPRV infected PBMCs. miR-210 that inhibits apoptosis was downregulated. miR-21-5p that decreases the sensitivity of cells to the antiviral activity of IFNs and miR-30b that inhibits antigen processing and presentation by primary macrophages were downregulated, indicative of a strong host response to PPRV infection. miR-21-5p was found to be inhibited on IPA upstream regulatory analysis of RNA-sequencing data. This miRNA that was also highly downregulated and was found to govern 16 immune response genes in the proteome data was selected for functional validation vis-a-vis TGFBR2 (TGF-beta receptor type-2). TGFBR2 that regulates cell differentiation and is involved in several immune response pathways was found to be governed by most of the identified immune modulating DEmiRNAs. The decreased luciferase activity in Dual Luciferase Reporter Assay indicated specific binding of miR-21-5p and miR-484 to their target thus establishing specific binding of the miRNAs to their targets.This is the first report on the miRNAome and proteome of virulent PPRV infected goat PBMCs.

Prevalence of Proteinuria and Albuminuria in an Obese Population and Associated Risk Factors

Obesity has been increasingly recognized as a risk factor for kidney disease and both proteinuria and microalbuminuria have been associated with obesity. The actual prevalence of microalbuminuria and proteinuria in obese patients in the United States (US) has not been clearly described in the literature. Furthermore, obesity is associated with risk factors of kidney disease, such as diabetes and hypertension (HTN), and the prevalence of proteinuria and albuminuria excluding these risk factors is uncertain. In this study, we collected urine albumin/creatinine and urine protein/creatinine ratios on obese patients undergoing bariatric surgery to determine the prevalence of albuminuria and proteinuria in obese patients with and without associated diabetes and HTN. The study included 218 obese patients undergoing bariatric surgery at a New York City hospital. The mean age was 42.1 ± 11.3 years. The mean body mass index (BMI) was 43.9 ± 8.1. Diabetes (DM) was present in 25%. HTN was present in 47%. The prevalence of proteinuria and albuminuria was 21% (95% CI: 15.8–27.1%) and 19.7% (95% CI: 14.2–26.2%) respectively. Among those without DM but who had HTN, 22.6% (95% CI: 12.9–35) had proteinuria and 17% (95% CI 8.4–30.9) had albuminuria. Of patients with neither DM nor HTN, 13.3% (95% CI: 7.3–21.6) and 11% (95% CI: 5–17%) had proteinuria and albuminuria, respectively. Diabetics had a significantly higher prevalence of proteinuria and albuminuria than the non-diabetic groups. The non-diabetic groups did not differ significantly from each other in terms of prevalence of proteinuria and albuminuria. The BMI for diabetics did not differ from non-diabetics. On multivariate analysis, only the presence of diabetes was associated with proteinuria and albuminuria. BMI, age, and HTN were not predictive. In conclusion, we found a relatively high prevalence of microalbuminuria and proteinuria in an urban, US, obese population undergoing bariatric surgery. When diabetics were excluded, there was a lower prevalence. Even patients who had neither diabetes nor HTN, still, however, had much greater amounts than seen in the general US population, likely reflecting an adverse effect of obesity itself on renal physiology.

nifPred: Proteome-Wide Identification and Categorization of Nitrogen-Fixation Proteins of Diaztrophs Based on Composition-Transition-Distribution Features Using Support Vector Machine