A Study on the Relevance of Feature Selection Methods in Microarray Data

This paper studies the relevance of feature selection algorithms in microarray data for effective analysis. With no loss of generality, we present a list of feature selection algorithms and propose a generic categorizing framework that systematically groups algorithms into categories. The generic categorizing framework is based on search strategies and evaluation criteria. Further, it provides guidelines for selecting feature selection algorithms in general and in specific to the context of this study. In the context of microarray data analysis, the feature selection algorithms are classified into soft and non-soft computing categories. Their performance analysis with respect to microarray data analysis has been presented.

Role of Ultrasound in the Synthesis of Nanoparticles and Remediation of Environmental Pollutants

Biosorptive Removal of Cadmium by Tinospora cordifolia (Wild Giloy)

This research reports the efficacy of Tinospora cordifolia as a biosorbent for removing cadmium ions from industrial effluents. The biosorption capacity was found to be 38.91 mg Cd/g and 43.06 mg Cd/g, in batch and column mode experiments, respectively. The work included uptake capacity, an equilibrium study, and a column study at varying pH (1–9), contact time (5–240 min), biosorbent dosages (1–8 g), and initial metal concentration (10–1000 mg/L). Both Langmuir and Freundlich isotherm models were applied to study the dose–response behavior, and it was observed that the Freundlich model provided the highest R 2 value. Fourier transform infrared spectroscopy (FTIR) analysis indicated the involvement of hydroxyl, alkane, anhydride, halide, and amine functional groups. Multilayer adsorption as indicated by the Freundlich adsorption model, and multifunctional group interaction as identified in the FTIR analysis, explains the high adsorptive capacity. The biomass was successfully applied for the removal of cadmium from industrial effluents. Biosorbent also gave a higher removal percentage at a low pH value (pH 2). The feasibility and viability of the biomass for technocommercial utilization in effluent treatment appears high.

Biochemical Characterization of H2O2-Induced Oxidative Stress in E.coli

Evaluation of Biotechnological Potential of Novel Mercury Tolerant Strain of Klebsiella Pneumonia

Role of host transcription factors in modulating defense response during plant-virus interaction

Surfacing the role of epigenetics in host-virus interaction

Compact XOR and XNOR logic gates using nonlinear plasmonic two-mode waveguide

AMELIORATIVE EFFECT OF NARINGENIN AGAINST ANTITUBERCULOSIS DRUGS INDUCED ALTERATIONS IN HEMATOLOGICAL PARAMETERS OF RATS

Objective: The aim of the present study was to evaluate the efficacy of naringenin against antituberculosis drugs (ATDs) induced alteration in hematological parameters in rats.Methods: Rats were administered with ATDs for 8 weeks (3 days/weeks) followed by naringenin at three different doses (10, 20, and 40 mg/kg) conjointly for 8 weeks (3 days/weeks) orally. After 8 weeks, animals were euthanized; blood was collected by retro-orbital sinus method for the analysis of hematological parameters.Results: The results of this study show decreased in red blood cells, hemoglobin, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, platelets, and eosinophils along with increase in the number of lymphocytes in ATDs induced rats. Treatment with naringenin encountered ATDs induced hematological parameter alteration which was evident by significant reversal in hematological indices toward control in dose-dependent manner.Conclusion: The present study concluded that ATDs exposure caused adverse effects in various blood components and conjoint treatment of naringenin reduced hematological alterations toward control due to antioxidant activity.

EFFECT OF RUTIN AGAINST HIGH-FAT DIET AND ALCOHOL-INDUCED ALTERATIONS IN HEMATOLOGICAL VARIABLES OF RATS

Objectives: Alcohol abuse leads to several diseases and millions of death worldwide. High-fat diet (HFD) is major contributor of non-alcoholic liver diseases and obesity. Combined consumption of HFD and alcohol has deleterious effect on blood cells. This study was carried out to evaluate the protective effect of rutin against combined consumption of HFD and alcohol-induced hematological alterations.Methods: HFD 30% and ethanol 10% were administered for 4 weeks for induction of toxicity. Rutin (10, 20, and 40 mg/kg) and 50 mg/kg dose of silymarin were administered along with HFD and alcohol for 4 weeks.Results: Combined consumption of HFD and alcohol increased mean corpuscular volume, total leukocytes count, eosinophil and monocyte, and decreased hematocrit and platelets. Administration of rutin improved hematological variables altered by HFD and alcohol consumption.Conclusion: The present study concluded that administration of rutin may alleviate HFD and alcohol-induced hematological alterations by scavenging free radicals generation.