Should the Qualitative Serum Pregnancy Test Be Considered Obsolete?

Qualitative and quantitative serum human chorionic gonadotropin (hCG) tests are used to diagnose pregnancy. We assessed physicians' perceptions and compared turnaround times (TATs) and performance characteristics of both tests. We surveyed 1,058 physicians about their perceptions of hCG tests. Seven months of TAT data were analyzed. hCG was measured in all qualitative samples. Pregnancy status was determined by chart review. Of the physicians surveyed, 183 responded. Forty-nine percent preferred qualitative over quantitative serum tests for determining pregnancy status. Physicians were willing to wait 45 minutes for results from either test. Qualitative tests are performed faster than quantitative tests, but TATs were not significantly different when sample transport time was considered. The negative predictive value of both tests was 99.9%. Qualitative serum hCG testing could be replaced by quantitative hCG tests, but there is no clear advantage to doing so.

Switch From Etravirine Twice Daily to Once Daily in Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI)-Resistant HIV-Infected Patients With Suppressed Viremia: The Monetra Study

Etravirine (ETR) is recommended as twice-daily dosing in pretreated patients. There are no data regarding the use of ETR once daily in HIV-experienced patients with prior resistance to first-generation non-nucleoside reverse transcripase inhibitors (NNRTIs).

Comparison of Functional Status Instruments in HIV-Infected Adults on Effective Antiretroviral Therapy

The best method for assessment of functional status in human immunodeficiency virus type 1 (HIV-1) infected persons is unknown.

Risk Factors for Posttraumatic Stress Disorder in Persons With Spinal Cord Injury

Many of the events that cause spinal cord injury (SCI) are traumatic events that can result in posttraumatic stress disorder (PTSD). It therefore appears that most persons with SCI are at risk for developing PTSD. This study retrospectively examined risk factors for PTSD symptoms in a sample of 71 persons with SCI.

Comparison of Unilateral Versus Bilateral Upper Extremity Task Performance After Stroke

Previous studies have suggested that practicing functional tasks bilaterally instead of unilaterally may improve paretic limb performance after stroke.

Functional Assessment of Spatial Neglect: A Review of the Catherine Bergego Scale and an Introduction of the Kessler Foundation Neglect Assessment Process

Spatial neglect is a debilitating poststroke neurocognitive disorder associated with prolonged hospitalization and poor rehabilitation outcomes. The literature suggests a high prevalence of this disorder, but clinicians have difficulty reliably identifying affected survivors. This discrepancy may result from suboptimal use of validated neglect assessment procedures. In this article, we suggest use of a validated assessment tool that is sensitive to identification of neglect and its functional consequences - the Catherine Bergego Scale (CBS). We provide detailed item-by-item instructions for observation and scoring - the Kessler Foundation Neglect Assessment Process (KF-NAP). Rehabilitation researchers may be able to use the CBS via the KF-NAP to measure ecological outcomes and specific, separable perceptual-attentional and motor-exploratory spatial behaviors.

Leading Innovation through Design: Proceedings of the DMI 2012 International Research Conference

The effectiveness of interventions aimed at improving access to health and mental health services for looked-after children and young people: a systematic review

Background: Compared with children and young people in the general population, looked after children and young people (LACYP) are more likely to experience behavioural, physical and psychological problems. Consequently, LACYP are likely to have greater need of health and mental health services to address any specific problems. This systematic review aimed to identify and synthesise evidence on the effectiveness of interventions to improve access to services accessed by LACYP. Methods: Searches of health, social science and social care databases were conducted and records were screened for relevance. Results: Five studies were included (four prospective cohort studies and one non-comparative study). There was considerable variation in terms of the services, interventions and outcomes reported. Conclusions: Little appropriate evidence was identified by this review, suggesting that the evidence base is at a very early stage.

An academic and voluntary sector collaboration to facilitate relationship support for ‘mixed’ couples and families

Working paper reporting on a collaboration between academics and the voluntary sector that aimed to develop online relationship resources and training modules for the benefit of ‘mixed’ couples and their children, health and social welfare practitioners and support groups: ‘The Facilitating Relationship Support for ‘Mixed’ Couples and Families: A Collaborative Approach and Evaluation’ project

Design and properties of biopolymer–silica hybrid materials: The example of pectin-based biodegradable hydrogels

The association of natural polymers with silica is a fruitful strategy to design novel hybrid structures with potential applications in the fields of biotechnology, medicine, and environmental sciences. Here we illustrate the principles of formation, the structure, and the properties of such biohybrid systems by the specific example of silica–pectin porous materials. The influence of the silica source, i.e., aqueous silicates and tetraethoxysilane (TEOS), was more specifically addressed. The alkoxide precursor may be associated with the polysaccharide in a wide range of concentrations. In contrast, the high initial viscosity and fast condensation rate of silicates limits the range of accessible compositions. Owing to weak interactions between the mineral and organic components, silicification does not improve the thermal stability of the polymer but has a strong impact on the water stability of the materials, which depends on the silica source. It is shown that the stability of the silica–pectin hybrid materials during enzymatic degradation is optimum for low carbohydrate content and high silica content, independently of the inorganic precursor.