Resource
2025 EN
Gürsoy Emrehan · Gürdal Mehmet · Gedik Engin
This study analyzed wind speed data for years in Karabük province, Türkiye, using an Artificial Neural Network (ANN) with a Multilayer Perceptron (MLP) feed-forward network. The Bayesian Regularization algorithm was employed, a well-known training algorithm for Multi-Layer Perceptron (MLP) networks. The study investigated the relationship between wind speed and various meteorological parameters such as month, air temperature, relative humidity, and air pressure. The results obtained from the ANN model provided a reliable methodology for predicting future wind speed values in Karabük province. To evaluate the performance of the ANN model, metrics such as Mean Absolute Error (MAE), Average Relative Deviation (ARD), Mean Squared Error (MSE), and R-squared (R 2 ) were utilized. The ANN model demonstrated its efficacy by revealing the highest average wind speeds of 2.7 m/s in Safranbolu province during August, with corresponding MAE, ARD%, MSE, and R 2 performance metrics of −0.029, −0.380%, 0.0028, and 0.999, respectively. The maximum measured and predicted Mean Wind Speed (MWS) values were identified in different months across various locations, specifically in August for Eflani, July for both Eskipazar and Karabük CC and September for Safranbolu. Notably, the highest recorded MWS was observed at 42.8 m/s in Eskipazar during July, while the lowest MWS was recorded at 16.4 m/s in Eskipazar in October. Besides, by employing Geographic Information System (GIS) analysis, the average wind speeds were ranked for different districts, with Safranbolu, Eflani, Eskipazar, and Karabük CC having the highest to lowest wind speeds, respectively.
Journals
2025 EN
Kahraman Erkan · Kalenderoglu Koray · Keskin Kivanc
+3 more
Left atrial appendage thrombus (LAAT) is the predominant etiology of ischemic stroke in patients with atrial fibrillation (AF), and LAAT is optimally demonstrated by transesophageal echocardiography (TEE). The study aimed to assess patients with nonvalvular atrial fibrillation (NVAF) identified with thrombus using TEE compared to those without thrombus, utilizing the C-reactive protein/albumin ratio (CAR) as a sensitive biomarker. This study was conducted retrospectively at a single center with 668 patients with NVAF who underwent TEE. Patients were divided into two groups based on the presence or absence of LAAT on TEE. The levels of CAR, C-reactive protein (CRP), neutrophil-lymphocyte ratio (NLR), and platelet-lymphocyte ratio (PLR) were compared. CAR was identified as an independent variable in patients with thrombus detected on TEE. (OR: 12.773, CI: 6.669–24.464, p < 0.001) Albumin was shown to have the highest area under the curve (AUC) value for thrombus prediction, followed by CAR, CRP, NLR, and PLR, in that order. (AUC: 0.999 CI: 0.993–1.000; 0.977 (0.962–0.987); 0.931 (0.909–0.949); 0.600 (0.562–0.937) p < 0.001, AUC: 0.574 CI: 0.535–0.612 p: 0.014) Our study demonstrates that CAR serves as an independent predictor of LAAT and shows more dependability than other biomarkers such as NLR, CRP, and PLR.
Journals
2025 EN
Seven İsmet · Karacan Mehmet Akif · Çelebi Semanur Özsan
+5 more
Metastatic non-small cell lung cancer (NSCLC) patients face a poor prognosis, with a 5-year overall survival (OS) rate of under 10%. In this investigation, we examined the prognostic implications of sarcopenia and metabolic metrics obtained from 18F-FDG PET/CT imaging in individuals diagnosed with metastatic non-squamous NSCLC (nsNSCLC). The investigation included 124 individuals with metastatic nsNSCLC who underwent 18F-FDG PET/CT imaging on diagnosis. Sarcopenia was determined by evaluating the skeletal muscle index at the L3 vertebral level. Metabolic metrics obtained from 18F-FDG PET/CT imaging, maximum standard uptake, metabolic tumor volume, and total lesion glycolysis were measured for whole body lesions (SUVmax_WB, MTV_WB, and TLG_WB) and primary tumors (SUVmax_T, MTV_T, and TLG_T). Primary endpoints examined were OS and the rate of sarcopenia diagnosis. Patients with sarcopenia, comprising 74.2% of the cohort, experienced a markedly reduced median OS of 4.7 months compared to 9.8 months in the non-sarcopenic cohort, which accounted for 25.8% of the population. Multivariate analysis revealed that sarcopenia, as well as metabolic metrics, including SUVmax_T, MTV_T, TLG_T, and SUVmax_WB, were independent predictors of OS in metastatic nsNSCLC patients. The presence of sarcopenia and unfavorable metabolic metrics on 18F-FDG PET/CT are linked to worse survival outcomes in metastatic nsNSCLC patients.
Journals
2025 EN
Kalkan Semih · Özkök Serçin · Demirtaş İhsan
+5 more
Late gadolinium enhancement (LGE) on cardiac magnetic resonance imaging indicates myocardial scarring and has prognostic value in myocarditis. The Pan-Immune-Inflammation Value (PIV) is a novel biomarker reflecting systemic inflammation; however, its association with LGE in myocarditis remains uninvestigated. This study aims to evaluate whether PIV levels can predict the presence of LGE in patients with myocarditis. We retrospectively analyzed 141 patients with myocarditis between 2021 and 2024. PIV, troponin levels, and other inflammatory markers were analyzed for their association with LGE. LGE was observed in 68.8% of the patients, with a higher proportion of males in the LGE+ group. The LGE+ group showed significantly elevated levels of PIV (1.661.2 ± 22.269) and troponin (786.2 ± 10.711 ng/L) compared to the LGE− group. Multivariate regression analysis confirmed PIV (OR: 1.002, p = 0.005) and troponin (OR: 1.003, p = 0.001) as predictors of LGE. ROC analysis identified a PIV threshold of >1153.2, achieving 95% specificity with a positive predictive value of 92.9% for LGE presence. Our findings indicate that elevated PIV levels are significant predictors of LGE, suggesting that PIV may serve as a valuable tool in assessing risk and guiding follow-up strategies for patients with myocarditis.
Journals
2025 EN
Kara Kanber · Kahraman Oğuzhan · İnal Fatma
+4 more
The aim of this study was to determine the effects of using black soldier fly ( Hermetia illucens ) (HI) at 0% (HI0), 7.5% (HI75) and 15% (HI150) larva meal instead of chicken meal in extruded dog food. A total of 18 Golden Retriever were used. In the study, HI larva meal was obtained and after detailed nutrient analysis, it was extruded as a dog food formulation instead of chicken meal. The foods were first subjected to in vitro digestion. Then, in vivo feeding in dogs was performed to determine preference test, digestion, blood variables and faecal microbiome, faecal score and organic acids. The HI larva meal up to 15% in dog food linearly increased the molarities of acetic (AA) and propionic (PA) acids in faeces ( p <.05), but linearly decreased the molarities of butyric (BA) and valeric (VA) acids ( p < 0.05). Iso -butyric (IBA), iso -valeric (IVA) and iso -caproic (ICA) acids in faeces decreased linearly with HI larva meal ( p < .05). The relative abundances of Phascolarctobacterium, Megamonas, Collinsella and Fournierella genera were higher in faeces of HI75 than those of HI0 ( p <.05). The relative proportion of Ligilactobacillus increased with HI larva meal ( p < .05). As a result, HI larva meal can be used up to 100% instead of chicken meal in extruded dog food without any negative effects on body weight, digestibility, faecal score, consumption preference, kidney-liver enzyme activities and immunological parameters. Besides, HI larva meal at 7.5% and 15% in extruded dog food had different effects on the faecal microbiome.
Journals
2025 EN
Clasen Frederick · Yildirim Suleyman · Arıkan Muzaffer
+12 more
The human microbiome is increasingly recognized for its crucial role in the development and progression of neurodegenerative diseases. While the gut-brain axis has been extensively studied, the contribution of the oral microbiome and gut-oral tropism in neurodegeneration has been largely overlooked. Cognitive impairment (CI) is common in neurodegenerative diseases and develops on a spectrum. In Parkinson’s Disease (PD) patients, CI is one of the most common non-motor symptoms but its mechanistic development across the spectrum remains unclear, complicating early diagnosis of at-risk individuals. Here, we generated 228 shotgun metagenomics samples of the gut and oral microbiomes across PD patients with mild cognitive impairment (PD-MCI) or dementia (PDD), and a healthy cohort, to study the role of gut and oral microbiomes on CI in PD. In addition to revealing compositional and functional signatures, the role of pathobionts, and dysregulated metabolic pathways of the oral and gut microbiome in PD-MCI and PDD, we also revealed the importance of oral-gut translocation in increasing abundance of virulence factors in PD and CI. The oral-gut virulence was further integrated with saliva metaproteomics and demonstrated their potential role in dysfunction of host immunity and brain endothelial cells. Our findings highlight the significance of the oral-gut-brain axis and underscore its potential for discovering novel biomarkers for PD and CI.
Journals
2025 EN
Elmanfi Samira · Onyedibe Kenneth I. · Aryal Uma K.
+3 more
Bacterial cyclic dinucleotides (CDNs), cyclic di-guanosine monophosphate (c-di-GMP), and cyclic di-adenosine monophosphate (c-di-AMP) upregulate interferon signaling proteins of human gingival fibroblasts (HGFs). However, the simultaneous effect of bacterial CDNs and lipopolysaccharides (LPS) on the HGF proteome is unknown. The aim was to apply an unbiased proteomics approach to evaluate how simultaneous exposure to CDNs and Porphyromonas gingivalis (Pg) LPS affect the global proteome of HGFs. The proteomic responses of HGFs were examined under three different treatment conditions (c-di-AMP+Pg LPS, c-di-GMP+Pg LPS, and Pg LPS alone) by label-free quantitative mass spectrometry analysis. Simultaneous exposure to CDNs and Pg LPS significantly upregulated innate immunity-related and interferon signaling-related proteins, such as ubiquitin-like protein ISG15 (ISG15), deoxynucleoside triphosphate triphosphohydrolase (SAMHD1), interferon regulatory factor 9 (IRF-9), interferon-induced GTP-binding protein Mx (MX)1, and MX2. Interferon signaling pathway was the most significantly regulated canonical pathway in both CDN treatment groups. Simultaneous exposure to CDNs and Pg LPS stimulates the periodontal immune response by activating the anti-microbial cellular responses of HGFs with some notable differences from individual exposures.
Journals
2025 EN
Kahraman Erkan · Kalenderoglu Koray
CHA2DS2-VASc and CHA2DS2-VA scores are often used to demonstrate thromboembolic risk in nonvalvular atrial fibrillation. Elevated whole blood viscosity is an independent risk factor for ischemic stroke. This study aimed to ascertain the correlation between whole blood viscosity and CHA2DS2-VASc/CHA2DS2-VA scores. This study was performed retrospectively in a tertiary cardiac facility, encompassing 150 patients. The study’s results demonstrate that whole blood viscosity, concerning both high shear rate and low shear rate variables, are statistically significant in forecasting the likelihood of elevated CHA2DS2-VA and CHA2DS2-VASc scores. ( AUC: 0.690, 0.693; p : <0.001; 0.647, 0.665; p : <0.05). Whole blood viscosity had a substantial correlation with the CHA2DS2-VASc/CHA2DS2-VA scores in patients with atrial fibrillation and may be used to evaluate thromboembolism risk, akin to these scores.
Journals
2025 EN
Nedim Bal Pervin · Kahraman Süleyman · Hündür Umut
The pervasive use of social media has given rise to new psychological challenges, including the fear of missing out (FOMO). Understanding how individuals cope with these challenges is crucial. From an Acceptance and Commitment Therapy (ACT) perspective, psychological flexibility is a key factor in managing these challenges effectively. correlational survey was conducted with 328 adults in Türkiye, utilizing the Mobile Social Media-Related Fear of Missing Out Scale and the Acceptance and Action Questionnaire II (AAQ-II) to collect data. Pearson correlation analysis revealed a weak, positive, and significant correlation between FoMO and AAQ-II scores, indicating that higher FoMO levels are associated with lower psychological flexibility. Comparison tests were conducted to examine differences in FoMO and AAQ-II scores based on demographic variables.
Journals
2025 EN
Hashmat Arshad · Ya Jingyuan · Kadir Rais
+2 more
Breakdown of blood-brain barrier (BBB) represents a key pathology in hyperglycemia-mediated cerebrovascular damage after an ischemic stroke. As changes in the level and nature of vasoactive agents released by endothelial cells (ECs) may contribute to BBB dysfunction, this study first explored the specific impact of hyperglycemia on EC characteristics and secretome. It then assessed whether secretome obtained from ECs subjected to normoglycaemia or hyperglycemia might regulate pericytic cytokine profile differently. Using a triple cell culture model of human BBB, composed of brain microvascular EC (BMEC), astrocytes and pericytes, this study showed that exposure to hyperglycemia (25 mM D-glucose) for 72 h impaired the BBB integrity and function as evidenced by decreases in transendothelial electrical resistance and increases in paracellular flux of sodium fluorescein. Dissolution of zonula occludens-1, a tight junction protein, and appearance of stress fibers appeared to play a key role in this pathology. Despite elevations in angiogenin, endothelin-1, interleukin-8 and basic fibroblast growth factor levels and a decrease in placental growth factor levels in BMEC subjected to hyperglycemia vs normoglycaemia (5.5 mM D-glucose), tubulogenic capacity of BMECs remained similar in both settings. Similarly, pericytes subjected to secretome obtained from hyperglycemic BMEC released higher quantities of macrophage migration inhibitory factor and serpin and lower quantities of monocyte chemoattractant protein-1, intercellular adhesion molecule, interleukin-6 and interleukin-8. Taken together these findings indicate the complexity of the mechanisms leading to BBB disruption in hyperglycemic settings and emphasize the importance of endothelial cell-pericyte axis in the development of novel therapeutic strategies.