Percutaneous coronary interventions (PCI) of coronary bifurcation lesions (CBL) are challenging lesions. Recently haemoglobin, albumin, lymphocyte, platelet index (HALP), has been used to determine the prognosis of many diseases and gives valuable information about the patient’s nutritional status and systemic inflammation. Our study aimed to assess the impact of HALP on long-term major advers cardiac events (MACE) for patients undergoing true coronary bifurcation stenting (CBS) procedure. A total of 773 patients who underwent percutaneous coronary intervention for true non-left main CBL were retrospectively enrolled. The primary clinical endpoint was MACE defıned as the occurence of target lesion revascularization (TLR), target vessel myocardial infarction (TVMI) or cardiac mortality. Secondary endpoint was stent thrombosis (ST). According to the best cut-off value of HALP score of 31.891, the study samples were divided into two groups. HALP score was negatively associated with the risk of MACE. Compared with patients whose HALP scores were >31.891, those who had HALP scores <31.891 seemed to have a high risk of MACE. In multivariate regression analysis HALP and CRP were determined as independent predictors of MACE. Kaplan-Meier survival curve analysis showed that the higher HALP group had a significantly better event-free survival regarding the occurrence of MACE, TVMI, TLR and cardiac mortality. Our study’s findings indicate that, HALP score was a significant independent predictor of long-term majör advers cardiovascular events in patients undergoing coronary artery bifurcation stenting procedure.
Liquid phase microextraction (LPME) with a dithizone/deep eutectic solvent (DTZ-DES)-based probe was employed for the determination of trace cadmium by flame atomic absorption spectrometry (FAAS). All extraction parameters were univariately optimized to achieve the highest efficiency and the limits of detection and quantification were 3.5 and 11.8 ng mL −1 . Good linearity was obtained from 10 to 200 ng mL −1 with a regression coefficient (R 2 ) of 0.9979. The sensitivity of FAAS system was improved 26.9-fold by the microextraction procedure. The accuracy and applicability of the method were investigated with recovery experiments carried out using corn silk tea extracts. The recovery values with matrix matching calibration were from 81.3 to 114.3%, demonstrating that this environmentally friendly method is applicable for determination of cadmium in tea samples with good accuracy.
Newborn screening and childhood immunization are among the most successful public health initiatives. Turkey has a high vaccination coverage (95–99%), but a recent decline is concerning. Vaccine hesitancy (VH) is a growing global issue, identified by the WHO as a major public health threat. Given that VH may correlate with attitudes toward other health practices, we explored whether early engagement with the health system via newborn screening influences childhood vaccine acceptance. Although these programs are implemented separately but concurrently as part of the national healthcare system in Turkey, integrating newborn screening and immunization initiatives may increase vaccine uptake through early engagement and trust building. This study aims to evaluate the relationship between newborn screening and parental vaccine hesitancy. This study was conducted at a tertiary care center in Turkey from July 2023 to April 2024. Parental VH was assessed using the PACV scale, along with questions on demographics and parental vaccination status. Participants with PACV score ≥ 50 were classified as VH+, others as VH–. Groups were compared using t-tests, Mann – Whitney U, chi-squared, or Fisher’s exact tests. Multiple logistic regression was used to analyze related factors. This analytic descriptive study included 481 parents (125 with children diagnosed with biotinidase deficiency or PKU via newborn screening, and 356 with healthy children aged 2–6). The mean age of respondents was 35 years, and the majority were mothers with a college education. The main sources of vaccine information were health professionals, followed by social media and family. Overall, 19.8% of parents were vaccine-hesitant, with a lower rate in the patient group (12% vs. 22.5%). VH was higher in fathers with chronic diseases (35.1% vs 18.1%, p = .012) and was lower in mothers received tetanus vaccine during pregnancy (16.1% vs. 30.6%, p = .001) or parents who received COVID-19 vaccine (mothers: 13.9% vs. 50.6%, fathers: 14.8% vs. 49.2%, both p < .001). VH was lower in those consulting healthcare professionals and higher in those relying on social media or non-medical sources. Diagnosis and treatment through newborn screening had an effect of 0.47 odds on VH in the overall group (95% CI = 0.24–0.92, p = .028). This study found lower vaccine hesitancy among participants in newborn screening programs and those whose parents received adult vaccinations, potentially due to increased contact with health professionals and greater health-seeking behavior. The influence of social media on vaccine hesitancy, evident in the general population, was not observed among cases, suggesting that systematic follow-up may buffer against external risk factors. Studies with matched cohorts, real-time data collection, and anonymous surveys are needed to improve generalizability, support causal inference, and reduce biases.
Bacterial cellulose (BC) has emerged as a promising biomaterial for biomedical applications due to its unique properties. In this study, firstly, the potential of BC as a carrier material for the originally synthesized benzyloxy pyridine derivative (BeOxP), and also an antimicrobial and probiotic bacteria-friendly (on Lactiplantibacillus plantarum 299v (LP299V ® ) (DSM 9843)) effect of BC- BeOxP was investigated. The BC- BeOxP composite material was developed using a simple and efficient method, ensuring the uniform dispersion of BeOxP within the BC matrix. Characterization of BeOxP has been carried out with High-Resolution Mass Spectroscopy (HRMS) and Nuclear Magnetic Resonance (NMR). Additionally, BC- BeOxP was characterized by Thermogravimetric analysis (TGA), Differential thermal analysis (DTA), Scanning Electron Microscopy (SEM), Texture analysis, and Fourier-transform infrared spectroscopy (FTIR), confirming the successful integration of BeOxP without compromising the structural integrity of BC. The mechanical properties of the BC- BeOxP composites were also evaluated to ensure their suitability for drug-carrying or food-packaging applications. Antimicrobial activity of the BC- BeOxP was analyzed against Staphylococcus aureus ATCC 29213 and Escherichia coli ATCC 25922 while the probiotic-friendly effect was tested on Lactiplantibacillus plantarum 299v (LP299V ® ) (DSM 9843). The findings open avenues for further research of BC-based drug carriers or packaging materials for advanced biomedical applications.