Antimicrobial activity of five essential oils from lamiaceae against multidrug-resistant Staphylococcus aureus

Analysis of Lamiaceae essential oils (EOs) by GC-FID-MS revealed the presence as the major constituents of linalool (16.8%), linalyl acetate (15.7%) in Lavandula angustifolia , menthol (29.0%), menthone (22.7%), menthyl acetate (19.2%) in Mentha x piperita , terpinen-4-ol (27.1%), (E)-sabinene hydrate (12.1%), γ -terpinene (10.0%) in Origanum majorana , α -thujone (19.5%), camphor (19.0%), viridiflorol (13.5%) in Salvia officinalis , thymol (61.9%), p -cymene (10.0%), γ -terpinene (10.0%) in Thymus vulgaris . Based on the MIC and MBC values (0.09-0.78 mg/mL) and ratio MBC/MIC showed that EO from T. vulgaris (TO) had the strong inhibitory and bactericidal effect against multidrug-resistan Staphylococcus aureus . The bacterial cells were total killed by TO at 2MIC concentration after 6 h. The higher concentrations of other EOs were needed to achieve bactericidal effects. The strong bactericidal effect of TO against these bacteria indicates the possibility of topical use of TO but it requires research under clinical conditions.

Cardiac macrophages promote diastolic dysfunction

Macrophages populate the healthy myocardium and, depending on their phenotype, may contribute to tissue homeostasis or disease. Their origin and role in diastolic dysfunction, a hallmark of cardiac aging and heart failure with preserved ejection fraction, remain unclear. Here we show that cardiac macrophages expand in humans and mice with diastolic dysfunction, which in mice was induced by either hypertension or advanced age. A higher murine myocardial macrophage density results from monocyte recruitment and increased hematopoiesis in bone marrow and spleen. In humans, we observed a parallel constellation of hematopoietic activation: circulating myeloid cells are more frequent, and splenic 18 F-FDG PET/CT imaging signal correlates with echocardiographic indices of diastolic dysfunction. While diastolic dysfunction develops, cardiac macrophages produce IL-10, activate fibroblasts, and stimulate collagen deposition, leading to impaired myocardial relaxation and increased myocardial stiffness. Deletion of IL-10 in macrophages improves diastolic function. These data imply expansion and phenotypic changes of cardiac macrophages as therapeutic targets for cardiac fibrosis leading to diastolic dysfunction.

Effect of Temperature and Time of Sintering to Doping Ag On Microstructure of Perovskite Material (La1-xAgx)0.8Ca0,2MnO3

Model of errors of touch-trigger probe installed on the industrial robot

Fire Safety Protection Assessment of Industrial Technologies

The effect of paraquat inhalation on parkinsonism, organ morphology and anatomy of mice and its recovery with the application ofetliringea hemisphaerica(blume, r.m. smith) crude extract

Studying metal impurities (Mn2+, Cu2+, Fe3+) in calcium phosphates by electron paramagnetic resonance

Synthesis carbon foams prepared from gelatin (CFG) for cadmium ion adsorption

Transport Properties and Magnetoresistance of La0.8Ca0.13Ag0.07MnO3 Perovskite Manganite Synthesized by Sol-Gel Method

Effect of Temperature and Duration of Sintering on Perovskite Material (La1-xAgx)0.8Ca0.2MnO3