Journals
2026 EN
Sandrine Visentin · Sophie Béliard · Cécile Renard
+8 more
ABSTRACT Purpose Metabolic syndrome (MetS) is a common complication in survivors of childhood acute lymphoblastic and myeloid leukemia (AL), and a major risk factor for premature cardiovascular disease, type‐2‐diabetes, and metabolic dysfunction‐associated steatotic liver disease (MASLD). Lifestyle interventions, including a healthy diet and physical activity, are the cornerstone of the management of MetS. In long‐term childhood AL survivors with MetS, the benefits of classical lifestyle interventions remain poorly documented. Methods We conducted a one‐year dietary and behavioral intervention with monthly dietitian coaching in this specific population. We assessed clinical, biological metabolic parameters, noninvasive biomarkers of hepatic steatosis and fibrosis, and eating habits at baseline and after one year of coaching. Results We enrolled 48 patients from the LEA cohort, diagnosed with MetS. The mean age was 32 years. At baseline, 62.2% of patients had hepatic steatosis and 15% had fibrosis F3–F4 (VCTE > 8 kPa). Daily energy intakes were already limited (average, 1611 Kcal/day). After one year of lifestyle coaching, the body mass index (27.1 vs. 26.5 kg/m 2 , p = 0.041) and the waist circumference (91.9 vs. 89.5 cm, p = 0.027) had decreased. Daily intakes had significantly decreased (1213 Kcal/day) with a healthier diet. Hepatic and metabolic parameters had not significantly improved in the study population. Liver steatosis was improved only in the subgroup of patients who lost weight and/or waist circumference. Conclusion Survivors of childhood AL have a high prevalence of MASLD at a young age. Classical lifestyle intervention appears incompletely efficient in improving metabolic and hepatic parameters in this specific population. New therapeutic approaches to reduce MetS and its complications in this unique population need to be studied.
Journals
2026 EN
Hosseinpour Zeinab · Bockfeld Dirk · Frank René
+1 more
An anionic N ‐heterocyclic carbene ligand with a weakly coordinating borate entity in the backbone (WCA‐NHC) is employed in the preparation of zwitterionic zinc complexes. Among these, zinc hydride species [(WCA‐IDipp)ZnH] 2 and [(WCA‐IDipp)ZnH(THF) 2 ] (WCA = B(C 6 F 5 ) 3 , IDipp = 1,3‐bis(2,6‐diisopropylphenyl)imidazolin‐2‐ylidene) were obtained either as a dinuclear zinc complex with two bridging hydrides or as a monomeric complex with a single terminal hydride, respectively. In these zwitterionic complexes, the positive charge at zinc is compensated by the anionic carbene ligand WCA‐IDipp. The overall neutral complexes display excellent solubility in organic solvents and were demonstrated as efficient catalysts in hydrosilylation reactions of aldehydes and ketones.
Journals
2026 EN
Fatehi Fatemeh · Ghorbanoghli Zeinab · Kooshki Mahdieh
+7 more
ABSTRACT We report a biallelic likely pathogenic variant in the NRDC gene in two Iranian siblings with developmental delay, microcephaly, hypotonia, seizures, and absent speech. Exome sequencing (ES) identified a frameshift deletion in exon 15 of NRDC (NM_001101662.2): c.1702_1703del (p.Met568Valfs*2), confirmed to segregate with disease in the family. This is the second report implicating biallelic NRDC gene variants in neurodevelopmental disorders. Our findings expand the phenotypic spectrum and support a potential role for NRDC in severe neurodevelopmental delay.
Journals
2026 EN
Chimtali Peter Joseph · Ifayefunmi Olalekan Sanmi · Qian Fangren
+8 more
In order to understand the anode‐electrolyte chemical interface, a dual salt‐dual solvent electrolyte was designed by including trace quantities of Cl − ions into the 1.5 M ZnSO 4 ‐H 2 O‐DEHMP electrolyte. Combination of experimental characterization techniques and theoretical calculations reveal that Cl − exhibits multifunctional electrolyte regulatory capabilities, including strong zincophilicity and reconfiguration of the hydrogen bond network in free water. Additionally, the chloride anions modify the charge transfer kinetics by reducing the high charge impedance in the electrolyte containing only DEHMP, hence facilitating optimal ionic conductivity for the Cl − and DEHMP electrolyte system. Meanwhile, the DEHMP significantly modifies the solvation shell and produces solid electrolyte interface layer advantageous for stabilizing the Zn anodes. Through the synergistic effect of Cl − anions and DEHMP, both parasitic reactions and dendrites growth are significantly diminished. Consequently, the Zn||Zn symmetric cell exhibited improved stability and reversibility over 1965 h at current density of 0.5 mA cm −2 and areal capacity of 0.5 mAh cm −2 . Meanwhile, the Zn||PANI full cell shows excellent stability in the hybrid electrolyte at 0.5 A g −1 .
Journals
2026 EN
Essa Ahmed F. · Elghonemy Mai M. · Abd Elkarim Asmaa S.
+6 more
ABSTRACT The rise of inflammation‐ and age‐related diseases reveals a need for safer therapies, with medicinal plants offering promising bioactive compounds for treatment. This study used chromatographic and NMR tools along with UHPLC‐ESI‐LIT‐Orbitrap‐MS to analyze the phytochemical profile of Euphorbia greenwayi 's main fractions (EG1:EG5), which showed promising dose‐dependent inhibition of COX‐1, COX‐2, and LOX enzymes through multivariate data analysis. A total of 125 metabolites were identified via UHPLC‐ESI‐LIT‐Orbitrap‐MS, including nine isolated and NMR‐structurally confirmed compounds, representing diverse chemical classes including phenolic acids and flavonoid glycosides as key components. Furthermore, this study utilized multivariate statistical methods, including Hierarchical Clustering Analysis (HCA) and Orthogonal Projection to Latent Structures Discriminant Analysis (OPLS‐DA), to classify solvent fractions based on their chemical composition. The results demonstrated significant dose‐dependent inhibitory effects of cyclooxygenase COX‐1, COX‐2, and lipoxygenase (LOX) enzymes. Notably, Fraction EG5 exhibited potent antiaging effects, as demonstrated by its inhibitory activity on collagenase and elastase enzymes. Further investigation revealed bioactive metabolites, such as xanthurenic acid, tricin, and quercetin, contributing to the anti‐inflammatory and antiaging properties. These findings provide valuable insights into the therapeutic potential of E. greenwayi , particularly for anti‐inflammatory and antiaging applications, and lay a foundation for future pharmacological studies on its bioactive compounds.
Journals
2026 EN
Chimtali Peter Joseph · Ifayefunmi Olalekan Sanmi · Qian Fangren
+8 more
ABSTRACT In the quest for cost‐effective and safe aqueous zinc ion batteries for specific applications, resourceful biomaterials have garnered significant attention due to their diverse surface chemistry, structural diversity, biocompatibility, and environmental friendliness. Herein, we mitigate water activity and the proliferation of zinc dendrites by integrating fresh ginger, which contains the main component (5S)‐5‐hydroxy‐1‐(3‐hydroxy‐4‐methoxyphenyl)decan‐3‐one (denoted as 6G), into the aqueous ZnSO 4 electrolyte (ZSO). This straightforward method demonstrates that the 6G electrolyte additive not only alters the initial hydrogen bond but also creates an extraordinary Zn 2+ solvation shell. In situ optical microscopy further validates the homogeneous and dense deposition of zinc, attributed to the adsorption of 6G on the zinc slab. The innovative ZSO+6G electrolyte provides Zn||Zn symmetric cells with exceptional cycle stability for 1550 h at a current density of 0.2 mA cm −2 . Meanwhile, the Zn||Cu asymmetric cell attains an impressive average Coulombic efficiency of 99.26% at 1 mA cm −2 . This study introduces an appealing method for optimizing electrolytes using bio‐materials to adjust coordination chemistry for the enhancement of durable zinc anodes.
Journals
2026 EN
Essa Ahmed F. · Ahmed Rania F. · ElGendy Zeinab A.
+7 more
ABSTRACT The Euphorbia greenwayi essential oil (EGEO) was analyzed by GC–MS, and 17 components were identified, accounting for 99.70%, predominantly monoterpene (98.28%). The major components were limonene (26.46%), α‐pinene (18.50%), 1,8‐cineole (25.62%), β‐pinene (6.52%), and γ‐terpinene (4.36%). Antioxidant potential was evaluated using DPPH and ABTS radical scavenging assays. The EGEO exhibited dose‐dependent activity, with respective IC 50 values of 417.7 and 448.8 mg/L, indicating moderate antioxidant capacity. Cytotoxic activity was assessed on THLE‐2 (normal liver), MCF‐7 (breast cancer), and HepG2 (liver cancer) cells. The EGEO exhibited negligible cytotoxicity toward THLE‐2 cells (> 93% viability at 0.1–500 µg/mL), while showing pronounced cytotoxicity against MCF‐7 cells (IC 50 = 166.65 µg/mL) and moderate activity against HepG2 cells (IC 50 = 328.03 µg/mL), highlighting selective antiproliferative effects. Molecular docking further substantiated the anticancer potential of EO constituents. Limonene demonstrated the strongest binding affinity against aurora kinase A (−10.586 kcal/mol) and the tumor suppressor PTEN (−6.397 kcal/mol), outperforming other tested monoterpenes. It established key interactions with hinge (Ala273), DFG motif residues in aurora A, and P‐loop residues (Cys124, Arg130) in PTEN, positioning it as a dual‐target lead compound. Sabinene also showed favorable binding to aurora A (−9.964 kcal/mol) but was less active toward PTEN. These findings suggested that EGEO possesses promising antioxidant and anticancer properties, with limonene emerging as a potential multitarget therapeutic agent for oxidative stress‐related and proliferative disorders.
Journals
2026 EN
Seifodin Fatemeh · Akbari Ahmad · KhaniArani Zeinab
Abstract The purpose of this research work is to develop a new nanofiltration membrane based on polyacrylonitrile (PAN) by ultraviolet photografting using acrylic acid as a vinyl monomer. This work represents a novel lead for applying new resources in activating PAN‐based membranes for photopolymerization reaction. Compared to traditional techniques that could only use photoactive membrane substrates, this method is an efficient procedure that shows a new perspective. Acid red 114, an azo dye, was used as photoinitiator in membrane surface modification process. The influence of different parameters on the grafting process such as irradiation time and monomer concentration on the performances and the characteristics of the membranes were examined. The grafted membrane in optimal condition was also evaluated for the removal of different salt solutions and different anionic direct dyes with the aim of reusing the dye and water in the process. Characterization of the modified membrane is performed by AFM, SEM, contact angle, and zeta potential. The retention of Na 2 SO 4 , MgSO 4 , NaCl, and CaCl 2 salts was obtained as 76%, 63.2%, 29.4%, 23.3%, and the retention of coloured pollutants DB15, DR16, DO26, and DY12 was acquired as 96.3%, 92.5%, 91.3%, and 85%, respectively. Distilled water permeability of photo‐grafted membrane was 13 L · h −1 · m −2 · bar −1 .
Journals
2026 EN
AlKabbany Abdullah Mohamed · Helmy Zeinab Ahmed · Nabi Ahmed Moustafa AbdEl
+2 more
As time progresses, the need for self‐powered sensing devices and new sources of energy grows. The triboelectric nanogenerator (TENG), which utilizes contact triboelectrification and electrostatic induction to produce energy, has emerged as an important invention that shows promise in satisfying both needs. One design of the TENG which uses electrostatic breakdown instead of electrostatic induction is the direct‐current TENG (DC‐TENG). DC‐TENGs require the attachment of a charge collecting electrode (CCE) behind a friction electrode (FE) which slides on a triboelectric layer (TL). The CCE must have a small distance between itself and the TL on which the TENG slides but is prohibited from touching the TL. This state can be difficult to achieve and maintain. This article proposes a DC‐TENG with a trailing free‐floating charge collecting electrode (FFCCE) which can be more easily separated from the TL by lubrication of the TL. The DC‐TENG w/ FFCCE was then compared to a traditional DC‐TENG and was found to have almost 2.43 times the power output of a non‐lubricated traditional DC‐TENG at low external resistances and had a comparable performance to a lubricated traditional DC‐TENG at the same low resistance range.
Journals
2026 EN
Rahmanian Reza · Shaygantabar Mohsen · Hekmatdoost Azita
+6 more
ABSTRACT Non‐soy legumes are rich in protein, fiber, and phytochemicals that may contribute to the prevention and management of obesity. Previous reviews have not specifically evaluated non‐soy legumes or comprehensive body composition outcomes, highlighting the need for a focused meta‐analysis. This systematic review and meta‐analysis aimed to evaluate the effects of non‐soy legume consumption on body composition parameters in adults, based on evidence from randomized controlled trials. Comprehensive searches were conducted in PubMed, Scopus, Medline, Web of Science, Cochrane Library, and Google Scholar up to January 2024 to identify eligible randomized controlled trials assessing the effects of non‐soy legumes on body weight, body mass index (BMI), waist circumference (WC), and fat mass (FM). Weighted mean differences (WMDs) and 95% confidence intervals (CIs) were calculated using a random‐effects model. Heterogeneity, subgroup analyses, meta‐regression, sensitivity analyses, and publication bias were evaluated using standard statistical methods. Thirty‐six trials met the inclusion criteria. Non‐soy legume consumption significantly reduced WC (WMD: −1.61 cm; 95% CI: −2.06, −1.16; p < 0.001), FM (WMD: −2.00 kg; 95% CI: −2.24, −1.78; p < 0.001), and body weight (WMD: −0.98 kg; 95% CI: −1.63, −0.33; p = 0.003). No significant effect was observed for BMI (WMD: −0.24 kg/m 2 ; 95% CI: −0.50, 0.03; p = 0.08). Subgroup analyses indicated that the effects varied according to intervention duration, participant age, and baseline BMI. Non‐soy legume consumption is associated with significant reductions in body weight, waist circumference, and fat mass, but not BMI. These findings support the potential role of non‐soy legumes in improving anthropometric measures related to obesity, although further high‐quality trials are needed to confirm these effects.